Archive: December 2017

Strategies to Manage Chemotherapy-Induced Peripheral Neuropathy

Manish R. Sharma, MD

  H&O  How common is chemotherapy-induced peripheral neuropathy? MS Chemotherapy-induced peripheral neuropathy (CIPN) is almost universal with certain neurotoxic drugs. Two types of therapies are classically […]

ALK Inhibitors in Non–Small Cell Lung Cancer: How Many Are Needed and How Should They Be Sequenced?

Alice T. Shaw, MD, PhD

  H&O  Which patients with non–small cell lung cancer (NSCLC) are candidates for treatment with crizotinib? AS  Crizotinib (Xalkori, Pfizer) is a multitargeted tyrosine kinase inhibitor […]

Monitoring Multiple Myeloma

Kyle A. Udd, BS, Tanya M. Spektor, PhD, and James R. Berenson, MD

  Abstract:  Multiple myeloma (MM) is a B-cell malignancy characterized by the accumulation in bone marrow of terminally differentiated plasma cells. MM is a slowly growing, […]

The Promise of Immunotherapy in Anal Squamous Cell Carcinoma: A Novel Approach for an Orphan Disease

Benny Johnson, DO, and Cathy Eng, MD

  Abstract: An estimated 8200 men and women in the United States will receive a diagnosis of squamous cell carcinoma of the anal canal (SCCA) in […]

CME Opportunity: Chemotherapy-Induced Nausea and Vomiting: Strategies for Prevention and Treatment

Lee S. Schwartzberg, MD

  Download the PDF file for CME opportunity information. H&O  What is the pathophysiology of CINV? LS  A great deal is known about the pathophysiology of […]

Should Autologous Platelet-Rich Plasma Be Used in Patients With Hematologic Disease?

Arturo J. Martí-Carvajal, MD, PhD 

  H&O  What is autologous platelet-rich plasma, and how is it prepared? AMC  More than 30 years ago, Knighton and colleagues studied 49 patients with chronic, nonhealing cutaneous ulcers—including […]

Incorporating Monoclonal Antibodies Into the Management of Multiple Myeloma

Tomer M. Mark, MD, MSc

  H&O  How do monoclonal antibodies work? TM  Monoclonal antibodies are immunoglobulins (Igs) that are generated and manufactured to target a specific antigen present on a […]

Letter From the Editor: Protests

Brad S. Kahl, MD

I have been thinking about protests lately—largely in response to the NFL national anthem controversy, which has left me wondering about the most effective way to protest. […]

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