What Is the Optimal Duration of Adjuvant Therapy in Colon Cancer? 

  H&O  Which patients with colon cancer require adjuvant therapy? AS  Patients who are considered to be at high risk for recurrence require adjuvant therapy. This […]

Locoregional Therapy for Liver Metastases in Colorectal Cancer

  H&O  How often does colorectal cancer (CRC) metastasize to the liver? AK  The exact frequency has been controversial for a long time. Current data suggest […]

Right-Sided vs Left-Sided Colorectal Cancer

  H&O  What is the definition of right-sided vs left-sided colon cancer? AV  In the analysis of the Cancer and Leukemia Group B (CALGB)/SWOG 80405 trial […]

Should We Consider Adjuvant Therapy for Rectal Cancer After Neoadjuvant Chemoradiotherapy?

  H&O  How common is rectal cancer? AB  In 2016, we can expect nearly 40,000 new cases. H&O  What is the standard treatment for locally advanced […]

Trifluridine/Tipiracil and Regorafenib: New Weapons in the War Against Metastatic Colorectal Cancer

  Abstract: Colorectal cancer (CRC) is the second leading cause of cancer-related death in the United States. Approximately 20% of patients have metastatic disease at diagnosis, […]

The Role of Microsatellite Instability Testing in Management of Colorectal Cancer

H&O What is microsatellite instability (MSI)? FS MSI refers to an accumulation of errors within microsatellite regions of DNA that lead to hypermutation and are caused […]

HER2 Testing in Metastatic Colorectal Cancer: Ready for Prime Time?

H&O What are the limitations of the current treatments for colorectal cancer? HH Our current therapies for colorectal cancer are effective for many patients, and much […]

Options for Second-Line Treatment in Metastatic Colorectal Cancer

  Abstract: Colorectal cancer (CRC) remains a major public health problem in the United States and worldwide. The majority of patients who have CRC eventually present […]