Patient-Derived Tumor Xenograft Models in Drug Development

  H&O  What types of preclinical models are used to predict clinical activity of novel therapies in cancer patients? MH  There are now 4 types of […]

Direct-to-Consumer Advertising of Cancer Treatments

  H&O  What have studies shown about direct-to-consumer advertising of medical treatments? LS  A few studies have evaluated direct-to-consumer advertising of medical treatments, but they are […]

The Value in Cancer Care Consortium: Addressing Financial Toxicity

  H&O  What is the Value in Cancer Care Consortium? AL  The Value in Cancer Care Consortium is a group of physicians who have come together […]

Recent Insights Into the Use of Combination Immunotherapy in Solid Tumors

  H&O  What are the main targets of immunotherapy? JL  In solid tumors, immunotherapy currently focuses the most on the checkpoint proteins cytotoxic T-lymphocyte–associated protein 4 […]

How Direct-to-Patient Research Can Improve Interest in Clinical Trials

  H&O  What are the challenges involved in patient recruitment and retention in traditional clinical trials? DC  There are so many challenges. For example, most traditional […]

The Evolving Role of Cyclin-Dependent Kinase Inhibitors in Cancer Management

  H&O  What is the role of cyclin-dependent kinases, and why are they a target in cancer treatment? GS  The cyclin-dependent kinases (CDKs) are a large […]

The Seamless Approach to Drug Development in Oncology

  H&O  What are some drawbacks to the 3-phase approach to drug development? RP  A major drawback to the conventional 3-phase program is that a stop […]

The Use of Drug Transporters as Therapeutic Targets

H&O  What is the role of transporters in cell biology? KG  Transporters are proteins that play a role in bringing small molecules—such as endogenous compounds, vitamins, […]

Manipulating the Microbiome to Improve the Efficacy of Immunotherapy

H&O What is known about the role of the gut microbiome in cancer? TG Research into the intersection between the commensal microbiota and cancer is just […]

FDA Regulation of Laboratory-Developed Tests

Clinical Advances in Hematology & Oncology Volume 14, Issue 5, May 2016 Vincent A. Miller, MD Chief Medical Officer Foundation Medicine Cambridge, Massachusetts H&O How are […]