From Recent Issues

Clinical Applications of PARP Inhibitors in Breast, Ovarian, and Prostate Cancer: Current Insights and Future Directions

Abstract: Poly(ADP-ribose) polymerase (PARP) inhibitors have emerged as an important therapeutic option for patients with homologous recombination repair (HRR)–deficient cancers, especially those with BRCA1/2 mutations. Since […]

Hemophagocytic Lymphohistiocytosis: New Grading Classification and Targeted Therapies

Abstract: Hemophagocytic lymphohistiocytosis (HLH), both primary/familial HLH and secondary HLH, is associated with multiorgan dysfunction caused by excessive immune activation and cytokine release. The high morbidity […]

Is There an Optimal Sequential Order to Androgen Receptor Axis Therapeutics?

Abstract: The hormonal therapeutic landscape in prostate cancer has expanded greatly over the last few decades with the advent of abiraterone acetate and second-generation antiandrogens such […]

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Molecular Residual Disease (MRD) Testing: Advancing Clinical Decision-Making in Breast Cancer

Abstract: Circulating tumor DNA (ctDNA) is emerging as a clinically meaningful biomarker across multiple solid tumors, including breast cancer. Advances in personalized, tumor-informed whole-genome sequencing have enabled […]

Clinical Response With Cabozantinib Plus Nivolumab, a First-Line Therapy in Advanced Renal Cell Carcinoma: A Clinical Case Report

In the Clinic . . . SH is a 47-year-old woman with a history of hypothyroidism and menopause who was diagnosed in March 2019 with Fuhrman […]

Use of Ravulizumab in a Pregnant Patient With PNH: Case-Based Insights

About the Patient AK has been under the care of my practice for several years, and her case is notably complex (Table). This case demonstrates that, […]

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