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PARP Inhibitors in Metastatic Prostate Cancer: Current Evidence and Future Directions

Abstract: Inhibitors of poly(ADP-ribose) polymerase (PARPis) are an established treatment for homologous recombination repair gene-altered metastatic prostate cancer. The efficacy of PARPis—both as single agents and […]

From Recent Issues

PARP Inhibitors in Metastatic Prostate Cancer: Current Evidence and Future Directions

Abstract: Inhibitors of poly(ADP-ribose) polymerase (PARPis) are an established treatment for homologous recombination repair gene-altered metastatic prostate cancer. The efficacy of PARPis—both as single agents and […]

From ADAURA to LAURA: The Evolving Role of EGFR-Targeted Therapy in NSCLC

Abstract: Epidermal growth factor receptor gene (EGFR) mutations, most commonly involving exon 19 deletion or leucine-858-to-arginine substitution (L858R), define a biologically distinct subset of non–small cell […]

Neoadjuvant Therapies in High-Risk Localized Prostate Cancer: Past, Present, and Future

Abstract: Treatment for high-risk localized prostate cancer can be particularly challenging because of an elevated risk of disease recurrence. One of the proposed ways to improve […]

Supplements

Therapeutic Approaches in aRCC: Focus on Patient Selection for IO–IO vs IO–TKI

Therapeutic Approaches in aRCC: Focus on Patient Selection for IO–IO vs IO–TKI In the Clinic . . . Patient 1: Metastatic Recurrence 2 Years After Completing […]

How I Treat MDS/AML: Individualizing Therapy Based on Disease Biology, Patient Fitness, Molecular Features, and Treatment Goals

How I Treat MDS/AML: Individualizing Therapy Based on Disease Biology, Patient Fitness, Molecular Features, and Treatment Goals In the Clinic . . . Consider the following […]

Optimizing Treatment Sequencing in Renal Cell Carcinoma in an Evolving Therapeutic Landscape

Abstract: The management of renal cell carcinoma (RCC) continues to evolve as new combinations and therapeutic strategies are demonstrating benefit across lines of therapy. For patients […]