Delaying the Use of High-Dose Melphalan With Stem Cell Rescue in Multiple Myeloma Is Ready for Prime Time

Dickran Kazandjian, MD, and Ola Landgren, MD, PhD

Abstract: The significant advances made in the treatment of multiple myeloma (MM) have allowed for a paradigm shift away from the early use of high-dose […]

In This Issue

How Biosimilars Will Impact Costs and Care in Oncology

Gary H. Lyman, MD, MPH, FASCO, FACP, FRCP(Edin)

Insights Into Survivorship Care for Cancer Patients

K. Scott Baker, MD, MS

Prostate Cancer in Military Veterans

Bruce Montgomery, MD

New Drug Approvals in Acute Myeloid Leukemia: An Unprecedented Paradigm Shift

Noam E. Kopmar, MD, and Elihu H. Estey, MD

Cyclin-Dependent Kinase 4/6 Inhibition in the Treatment of Hormone Receptor–Positive Breast Cancer

Hope S. Rugo, MD

From Recent Issues

Phosphoinositide 3-Kinase Inhibition in the Treatment of Hormone Receptor–Positive Breast Cancer

H&O Which patients are eligible for treatment with alpelisib? HR One of the major advances this year in treating hormone receptor (HR)-positive breast cancer has […]

A Rational Approach to the Development of Drug Combinations in Thoracic Oncology

H&O What is the typical approach to the development of drug combinations in oncology? DRC In clinical trials, drug combinations can reflect several scenarios. A trial […]

Management of Rare Epithelial Ovarian Cancers

H&O What percentage of ovarian cancers are epithelial? DG Approximately 90% of all invasive ovarian cancers are epithelial. The other 2 major categories of invasive […]

Supplements

A New Strategy for Uncontrollable Bleeding After Treatment With Rivaroxaban or Apixaban

Abstract: Anticoagulants are used in several settings to reduce the risk of thromboembolic events, but they can be associated with severe complications, such as potentially fatal bleeding. […]

Highlights in Lymphoma From the 2019 American Society of Clinical Oncology Annual Meeting

A Review of Selected Presentations From the 2019 ASCO Annual Meeting • May 31-June 4, 2019 • Chicago, Illinois Brentuximab Vedotin With Chemotherapy for Stage 3/4 […]

Highlights in Chronic Lymphocytic Leukemia From the 2019 American Society of Clinical Oncology Annual Meeting

A Review of Selected Presentations From the 2019 ASCO Annual Meeting • May 31-June 4, 2019 • Chicago, Illinois Final Analysis From RESONATE: Six-Year Follow-Up in […]

Hematology

Diagnosis and Treatment of Hemophilia

Abstract: Hemophilia A and B are inherited bleeding disorders characterized by deficiency or dysfunction of coagulation protein factors VIII and IX, respectively. Recurrent joint and […]

Diagnosing or Ruling Out Polycythemia Vera in Patients With Erythrocytosis

H&O How is erythrocytosis defined? JP Erythrocytosis is the presence of too many red blood cells. Several different parameters are used to diagnose erythrocytosis in […]

Immune-Mediated Hemolytic Anemia and Thrombocytopenia in Clonal B-Cell Disorders: A Review

Abstract: Autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia purpura (ITP) have been associated with B-cell lymphoproliferative disorders. Here, we review the epidemiology, pathogenesis, diagnosis, and […]