Prostate Cancer
New Approaches to Immunotherapy for Metastatic Castration-Resistant Prostate Cancer
Breast Cancer
Treatment of Early-Stage Hormone Receptor–Positive Breast Cancer
Hope S. Rugo, MD
H&O What are the most important questions for oncologists treating patients with early-stage hormone receptor–positive, human epidermal growth factor receptor 2–negative breast cancer after surgery? HR […]
In This Issue
Drug Development
Targeting the KRAS G12C Mutation in Patients With Advanced Solid Tumors
David S. Hong, MD
Myeloma
HIV Protease Inhibitors for the Treatment of Multiple Myeloma
Max Mendez-Lopez, MD, Tabea Sutter, MD, Christoph Driessen, MD, and Lenka Besse, PhD
Cholangiocarcinoma
Molecular Pathways and Targeted Therapy in Cholangiocarcinoma
Raetasha S. Dabney, MD, Mustapha Khalife, MD, Kamran Shahid, MD, and Alexandria T. Phan, MD
From Recent Issues
Myeloma
Delaying the Use of High-Dose Melphalan With Stem Cell Rescue in Multiple Myeloma Is Ready for Prime Time
Abstract: The significant advances made in the treatment of multiple myeloma (MM) have allowed for a paradigm shift away from the early use of high-dose […]
Drug Development
How Biosimilars Will Impact Costs and Care in Oncology
H&O How does a biosimilar compare to a biologic therapy or a generic formulation? GL To start, it is necessary to distinguish biologic molecules from […]
Breast Cancer
Phosphoinositide 3-Kinase Inhibition in the Treatment of Hormone Receptor–Positive Breast Cancer
H&O Which patients are eligible for treatment with alpelisib? HR One of the major advances this year in treating hormone receptor (HR)-positive breast cancer has […]
Supplements
leukemia
Highlights From the XVIII International Workshop on Chronic Lymphocytic Leukemia
A Review of Selected Presentations From the XVIII iwCLL • September 20-23, 2019 • Edinburgh, Scotland Ibrutinib Versus Placebo in Patients With Asymptomatic, Treatment-Naive Early-Stage Chronic […]
hematology
A New Strategy for Uncontrollable Bleeding After Treatment With Rivaroxaban or Apixaban
Abstract: Anticoagulants are used in several settings to reduce the risk of thromboembolic events, but they can be associated with severe complications, such as potentially fatal bleeding. […]
lymphoma
Highlights in Lymphoma From the 2019 American Society of Clinical Oncology Annual Meeting
A Review of Selected Presentations From the 2019 ASCO Annual Meeting • May 31-June 4, 2019 • Chicago, Illinois Brentuximab Vedotin With Chemotherapy for Stage 3/4 […]
Hematology
Diagnosis and Treatment of Hemophilia
Abstract: Hemophilia A and B are inherited bleeding disorders characterized by deficiency or dysfunction of coagulation protein factors VIII and IX, respectively. Recurrent joint and […]
Diagnosing or Ruling Out Polycythemia Vera in Patients With Erythrocytosis
H&O How is erythrocytosis defined? JP Erythrocytosis is the presence of too many red blood cells. Several different parameters are used to diagnose erythrocytosis in […]
Immune-Mediated Hemolytic Anemia and Thrombocytopenia in Clonal B-Cell Disorders: A Review
Abstract: Autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia purpura (ITP) have been associated with B-cell lymphoproliferative disorders. Here, we review the epidemiology, pathogenesis, diagnosis, and […]