From Recent Issues

First-line Use of Antiangiogenic Agents in Unresectable Hepatocellular Carcinoma: A Double-Edged Sword?

Abstract: Treatment options for hepatocellular carcinoma (HCC), the most prevalent primary liver malignancy, have historically been limited, particularly in unresectable cases with underlying cirrhosis. Initial systemic […]

Revolutionizing Breast Cancer Treatment: The Promise of Antibody-Drug Conjugates

Abstract: Antibody-drug conjugates (ADCs) have significantly advanced the treatment of breast cancer by integrating the specificity of monoclonal antibodies with the cytotoxic efficacy of chemotherapy, thereby […]

Non–Clear Cell Renal Cell Carcinoma: Unpacking a Messy Term

Abstract: Non–clear cell renal cell carcinoma (nccRCC) is a heterogeneous category comprising approximately 25% of epithelial renal tumors. Unlike their far more common clear cell counterpart, […]

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Navigating the Paroxysmal Nocturnal Hemoglobinuria (PNH) Landscape

Abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disorder in which a somatic mutation in PIGA leads to reduced or absent expression of […]

The Promise of Molecular Residual Disease (MRD) Testing for Patients With Colorectal Cancer

Abstract: Molecular residual disease (MRD) assays using circulating tumor DNA (ctDNA) have the potential to detect colorectal cancer recurrence earlier than current standard-of-care surveillance techniques, such as […]

Modern Approaches in Neuroendocrine Tumors (NETs)

In the Clinic: Case Studies The following 2 patient cases highlight the clinical complexity of neuroendocrine tumors (NETs), and the widely different approaches in pancreatic NETs […]