Prostate Cancer
New Approaches to Immunotherapy for Metastatic Castration-Resistant Prostate Cancer
Colorectal Cancer
The Role of Comprehensive Molecular Profiling in Colorectal Cancer
Howard S. Hochster, MD
H&O What are the relevant mutations or other alterations that molecular profiling can pick up in colorectal cancer, and how common are they? HH The […]
In This Issue
Drug Development
Advances in the Development of Vaccines and Other Immunotherapies for Multiple Myeloma
David E. Avigan, MD
Leukemia
Treatment-Free Remission in Chronic Myeloid Leukemia
Matteo Molica, MD, Kiran Naqvi, MD, Jorge E. Cortes, MD, Shilpa Paul, PharmD, Tapan M. Kadia, MD, Massimo Breccia, MD, Hagop Kantarjian, MD, and Elias J. Jabbour, MD
Bladder Cancer
Bladder-Sparing Treatment of Nonmetastatic Muscle-Invasive Bladder Cancer
Kyle J. Ericson, MD, Prithvi B. Murthy, MD, Darren J. Bryk, MD, Rathika R. Ramkumar, MD, James R. Broughman, MD, Abhinav Khanna, MD, MPH, Omar Y. Mian, MD, and Steven C. Campbell, MD, PhD
Lymphoma
Prophylaxis of Central Nervous System Relapse in Patients With Lymphoma
Avyakta Kallam, MD
My First Year in Practice
Becoming a Surgeon-Scientist: My Transition From Fellowship to Faculty
Rebecca A. Previs, MD, MS
From Recent Issues
Breast Cancer
Treatment of Early-Stage Hormone Receptor–Positive Breast Cancer
H&O What are the most important questions for oncologists treating patients with early-stage hormone receptor–positive, human epidermal growth factor receptor 2–negative breast cancer after surgery? HR […]
Drug Development
Targeting the KRAS G12C Mutation in Patients With Advanced Solid Tumors
H&O What is the KRAS G12C mutation? DH RAS mutations are one of the most common mutations in cancer (after the P53 mutation). Estimates suggest […]
Myeloma
Delaying the Use of High-Dose Melphalan With Stem Cell Rescue in Multiple Myeloma Is Ready for Prime Time
Abstract: The significant advances made in the treatment of multiple myeloma (MM) have allowed for a paradigm shift away from the early use of high-dose […]
Supplements
leukemia
Highlights From the XVIII International Workshop on Chronic Lymphocytic Leukemia
A Review of Selected Presentations From the XVIII iwCLL • September 20-23, 2019 • Edinburgh, Scotland Ibrutinib Versus Placebo in Patients With Asymptomatic, Treatment-Naive Early-Stage Chronic […]
hematology
A New Strategy for Uncontrollable Bleeding After Treatment With Rivaroxaban or Apixaban
Abstract: Anticoagulants are used in several settings to reduce the risk of thromboembolic events, but they can be associated with severe complications, such as potentially fatal bleeding. […]
lymphoma
Highlights in Lymphoma From the 2019 American Society of Clinical Oncology Annual Meeting
A Review of Selected Presentations From the 2019 ASCO Annual Meeting • May 31-June 4, 2019 • Chicago, Illinois Brentuximab Vedotin With Chemotherapy for Stage 3/4 […]
Hematology
Diagnosis and Treatment of Hemophilia
Abstract: Hemophilia A and B are inherited bleeding disorders characterized by deficiency or dysfunction of coagulation protein factors VIII and IX, respectively. Recurrent joint and […]
Diagnosing or Ruling Out Polycythemia Vera in Patients With Erythrocytosis
H&O How is erythrocytosis defined? JP Erythrocytosis is the presence of too many red blood cells. Several different parameters are used to diagnose erythrocytosis in […]
Immune-Mediated Hemolytic Anemia and Thrombocytopenia in Clonal B-Cell Disorders: A Review
Abstract: Autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia purpura (ITP) have been associated with B-cell lymphoproliferative disorders. Here, we review the epidemiology, pathogenesis, diagnosis, and […]