Feature Article

Hemophagocytic Lymphohistiocytosis: New Grading Classification and Targeted Therapies

Abstract: Hemophagocytic lymphohistiocytosis (HLH), both primary/familial HLH and secondary HLH, is associated with multiorgan dysfunction caused by excessive immune activation and cytokine release. The high morbidity […]

Prostate Cancer In Focus

The Addition of PARP Inhibition to Androgen Receptor Pathway Inhibition in Metastatic Hormone-Sensitive Prostate Cancer

H&O What was the rationale for conducting the AMPLITUDE trial?1 GA We were trying to solve 2 problems. First, although 30% of patients who are started […]

Lung Cancer in Focus

Updates in the Management of Small Cell Lung Cancer

H&O How common is small cell lung cancer (SCLC), and what are the characteristics of this subtype of lung cancer? JM SCLC accounts for up to […]

Advances in Hematology

Periprocedural Management of Patients on Antithrombotic Therapy

H&O How common is it for surgical patients to be on an antiplatelet or anticoagulant agent? RM Antiplatelet therapy includes aspirin and the P2Y12 antagonists clopidogrel, […]

Gynecologic Cancer in Focus

Update on Immune Checkpoint Inhibition for Cervical Cancer

H&O What is it about the biology of cervical cancer that makes it an attractive target for immune checkpoint inhibition? LD More than 98% of cases […]

Advances in Drug Development

How to Implement DPYD Genotyping Into Practice

H&O Can you explain what the dihydropyrimidine dehydrogenase (DPYD) gene does? AV The DPYD gene encodes the dihydropyrimidine dehydrogenase (DPD) enzyme, which degrades excess thymine and […]