Antibody-Drug Conjugates in Advanced Lung Cancer: Is This a New Frontier?

Abstract: Over the past decade, the lung cancer landscape has been dominated by targeted and immunotherapeutic approaches that have drastically shifted treatment paradigms for patients with […]

Redefining the Standard of Care for Low-Grade Serous Ovarian Cancer

Abstract: Low-grade serous carcinoma is a rare epithelial ovarian cancer subtype with distinct clinical, histologic, and molecular features. Improved understanding of this disease subtype has prompted […]

The Evolving Role of Surgery in Melanoma

H&O  What has been the traditional role of surgery in melanoma? VKS  Surgery has long been the mainstay of treatment for all early-stage melanomas. We used […]

Pirtobrutinib in Relapsed or Refractory CLL and SLL

H&O  What are the mechanisms of action of pirtobrutinib and other Bruton tyrosine kinase (BTK) inhibitors? JW  All of the currently available BTK inhibitors work by […]

New Drug Approvals for Prostate Cancer

H&O  What are the most recent drug approvals for prostate cancer? IT  The most recent drug approvals for men with prostate cancer primarily consist of “me-too” […]

STEAP1 as a Potential Target for New Therapies in Prostate Cancer

H&O What is six-transmembrane epithelial antigen of prostate 1 (STEAP1)? WKK STEAP1 was first described more than 2 decades ago. It is a cell-surface antigen that […]

Immune Checkpoint Inhibitor Therapy in Locally Advanced MSI GI Malignancies

Abstract: Locally advanced gastrointestinal (GI) malignancies have conventionally been treated in a multimodal fashion that combines (neo)adjuvant chemotherapy with or without radiation and definitive surgical resection. […]

Increasing Inclusion and Equity for Black Women in Breast Cancer Clinical Trials

Abstract: Black women diagnosed with breast cancer experience a disproportionately high mortality rate. The disparity in outcomes between Black and White women is multifactorial, with a […]

The Development of Menin Inhibitors in AML and ALL

H&O  What are menin inhibitors, and how do they function in the context of acute myeloid leukemia/acute lymphoblastic leukemia? GI  Menin inhibitors are a new form […]

PROTAC Drugs in Cancer Care

H&O  What are PROTACs, and how do they target proteins in cancer treatment? PF  Proteolysis-targeting chimeras (PROTACs) are a new class of drugs that, in my […]

Liver Transplant in Patients With Metastatic Colorectal Cancer

H&O  How common are liver-limited metastases in colorectal cancer (CRC)? BA  Approximately one-third of patients with metastatic CRC (mCRC) have metastases that are isolated to the […]

Case Study Series: Improving Outcomes in Pediatric NTRK Gene Fusion-Positive Solid Tumors: Importance of Genomic Testing and Targeted Therapy With the TRK Inhibitor Larotrectinib

In the Clinic: Case Studies Let us begin our discussion with 2 pediatric cases that prompt the question, “How will you proceed?” Patient 1: A baby […]

Back to Archive