Feature Article

Targeted Immunotherapy in the Treatment of Childhood and Adolescent Classic Hodgkin Lymphoma

Abstract: Childhood and adolescent classic Hodgkin Lymphoma (cHL) has long been a model for how we balance improved outcomes with increased toxicities in pediatric cancer. The […]

Feature Article

The Emergence of Bispecific T-Cell Engagers in the Treatment of Follicular and Large B-Cell Lymphomas

Abstract: The rapid emergence of CD20-targeting T-cell engagers in follicular lymphoma and large B-cell lymphoma has further expanded the treatment options for patients with relapsed or […]

Letter From the Editor

Letter From the Editor: Who’s Your Advocate?

I don’t think we oncologists fully appreciate just how fortunate we are to have advocacy groups in our field. Most other fields of medicine would love to […]

Prostate Cancer In Focus

Incorporating PSMA PET Imaging Into the Treatment Plan for Newly Diagnosed and Recurrent Prostate Cancer

H&O What are the advantages of prostate-specific membrane antigen positron emission tomography (PSMA PET) over conventional imaging for prostate cancer? NS Conventional imaging, which has been […]

Melanoma in Focus

What Will Be the Next Partner for Combination Immunotherapy With Nivolumab and Ipilimumab?

H&O Which patients with melanoma are eligible for treatment with the combination of nivolumab (Opdivo, Bristol Myers Squibb) plus ipilimumab (Yervoy, Bristol Myers Squibb)? JL The […]

CLL

Choosing Between CAR T-Cell Therapy and Pirtobrutinib in Double-Refractory CLL

H&O What does it mean to have double-refractory chronic lymphocytic leukemia (CLL)? KR We do not have a definition that everyone in the field agrees with […]

Clinical Update

The Use of Zenocutuzumab for NRG1 Fusion–Positive Tumors

H&O What type of testing is used to detect clinically relevant gene fusions? AS Gene fusions can be detected using DNA- or RNA-based assays; however, RNA […]

Breast Cancer In Focus

Circulating Tumor DNA in Early-Stage Breast Cancer: Ready for the Clinic?

H&O What are the different techniques or technologies that are used to evaluate circulating tumor DNA (ctDNA) in breast cancer? HP Currently, 3 general categories of […]