Feature Article

Clonal Hematopoiesis: Malignant Implications, Extrahematologic Manifestations, and Management

Abstract: As individuals age, their hematopoietic stem cells can sporadically acquire genetic mutations, known as clonal hematopoiesis. Although most of these genomic aberrations are of little […]

Lung Cancer in Focus

HER2-Targeted Therapies in Non–Small Cell Lung Cancer

H&O What types of human epidermal growth factor receptor 2 (HER2) alterations occur in non–small cell lung cancer (NSCLC)? JM We see several types of targetable […]

Advances in LLM

Can We Cure Ph+ ALL Without Chemotherapy or Transplant?

H&O What is Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL), and how is it typically managed? RF Ph+ ALL is the most frequent genetic ALL subgroup […]

Advances in Drug Development

STING Activators in Cancer Care

H&O What are STING activators, and how do they play a role in cancer immunotherapy? RS The stimulator of interferon genes (STING) pathway plays a crucial […]