Tags: AML
IDH Inhibitors in Acute Myeloid Leukemia and Myelodysplastic Syndrome
H&O How common are isocitrate dehydrogenase (IDH) mutations in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)? ES At diagnosis, approximately 20% to 25% […]
Alternatives to Intensive Treatment in Patients With AML
Abstract: A significant proportion of patients with acute myeloid leukemia (AML) are unable to tolerate standard induction chemotherapy regimens. This is particularly true for patients who […]
FLT3 Inhibitors in Acute Myeloid Leukemia: Increasing Options
H&O What are the current treatments for acute myeloid leukemia (AML)? TK In the past 5 years, the US Food and Drug Administration (FDA) has approved […]
Hypomethylating Agents and Venetoclax in Acute Myeloid Leukemia
H&O What are the outcomes associated with hypomethylating agents in acute myeloid leukemia (AML)? CD Decitabine and azacytidine, the hypomethylating agents typically used in this setting, […]
Evolving Strategies for the Management of Core-Binding Factor Acute Myeloid Leukemia
H&O What are core-binding factors? GB Core-binding factors are heterodimeric transcription factors that are necessary at different stages of hematopoiesis. Core-binding factor alpha has 3 […]
Assessing the Risk of Heart Failure in Patients With Acute Leukemia
H&O What is the risk of heart failure in patients with acute lymphoblastic leukemia or acute myeloid leukemia? MSC Heart failure in patients with acute […]
New Drug Approvals in Acute Myeloid Leukemia: An Unprecedented Paradigm Shift
Abstract: We are witnessing an unprecedented paradigm shift in the treatment of acute myeloid leukemia (AML). For nearly 4 decades—since the introduction of cytarabine- and anthracycline-based […]
Midostaurin for Patients With Acute Myeloid Leukemia and FLT3 Mutations
H&O What is the role of FLT3 in normal cells and acute myeloid leukemia? ML FLT3 is a receptor tyrosine kinase. The name stands for […]
Treatment Advances in Blastic Plasmacytoid Dendritic Cell Neoplasm
H&O What is blastic plasmacytoid dendritic cell neoplasm (BPDCN)? NP BPDCN is an aggressive cancer of the blood and bone marrow that presents clinically as […]
Hem/Onc News
Ivosidenib Approved for Relapsed or Refractory Acute Myeloid Leukemia On July 20, the US Food and Drug Administration (FDA) approved ivosidenib (Tibsovo, Agios) for adults with […]
Enasidenib for Relapsed/Refractory Acute Myeloid Leukemia With IDH2 Mutations: Optimizing the Patient Experience
H&O What is the mechanism of action of enasidenib? GR Enasidenib (Idhifa, Celgene/Agios) is an oral, small molecule inhibitor of mutant isocitrate dehydrogenase 2 (IDH2) […]
Enasidenib for Patients With Relapsed Acute Myeloid Leukemia and the IDH2 Mutation
H&O Which patients with AML are at higher risk for relapse? CD Unfortunately, most adult patients with acute myeloid leukemia (AML) will relapse. Features associated […]
A Mind Map for Managing Minimal Residual Disease in Acute Myeloid Leukemia
Abstract: Advances in detecting traces of leukemia that were previously unidentifiable have increasingly led to the incorporation of information about residual disease into clinical decision […]
Emerging Treatments in Acute Myeloid Leukemia: Current Standards and Unmet Challenges
Abstract: Acute myeloid leukemia (AML) is rare and difficult to treat. Although remission is achieved in most patients with newly diagnosed disease, relapse occurs in […]
The Evolution of Allogeneic Stem Cell Transplant for Children and Adolescents With Acute Myeloid Leukemia
Abstract: Survival rates in subsets of pediatric patients who have acute myeloid leukemia (AML) with favorable risk features are now greater than 90%. However, outcomes […]
Guideline Recommendations for the Prophylaxis of Invasive Aspergillosis in AML
Clinical Advances in Hematology & Oncology Volume 14, Issue 11, November 2016 Eunice S. Wang, MD Chief, Leukemia Service Professor of Oncology, Department of Medicine Roswell […]