EGFR Inhibition in Colorectal Cancer With Liver Metastasis

  H&O  What is the standard course of treatment for patients with metastatic colorectal cancer that has spread to the liver? AG  The first step in […]

How We Treat Left-Sided vs Right-Sided Colon Cancer

  Learning Objectives • To understand the biological and clinical differences between left-sided and right-sided colon cancer; • To identify appropriate therapies for patients with metastatic […]

When to Use Triplet Chemotherapy as First-Line Treatment in Metastatic Colorectal Cancer

  H&O  What are the options for first-line treatment in metastatic colorectal cancer (CRC)?  CC  First, I want to emphasize that chemotherapy still matters a great […]

Immunotherapy in Colorectal Cancer With Mismatch Repair Deficiency

  H&O  Which immunotherapy agents have been approved for use in colorectal cancer (CRC) with mismatch repair deficiency (MMR-D)? MO  We have a choice of 3 […]

Optimal Duration of Adjuvant Therapy for Stage III Colon Cancer

  Abstract:  Colon cancer remains a major cause of mortality worldwide. Following adequate surgical resection of lymph node–positive colon cancer, the standard of care since 2004 […]

How Should BRAF V600E–Mutated Colorectal Cancer Be Treated?

  H&O  How common is the BRAF V600E mutation in colorectal cancer (CRC), and how does it affect prognosis? SK  The BRAF V600E mutation is present […]

How I Treat Chemorefractory Metastatic Colorectal Cancer

  Learning Objectives • Identify the most appropriate systemic therapies for patients with chemorefractory metastatic colorectal cancer  • Determine the role of molecular sequencing in identifying […]

Immunotherapy in Colorectal Cancer 

  H&O  Is colorectal cancer (CRC) a good target for immunotherapy? DL  A subset of patients with CRC have tumors that are found to be deficient […]