EGFR Inhibition in Colorectal Cancer With Liver Metastasis

H&O What is the standard course of treatment for patients with metastatic colorectal cancer that has spread to the liver? AG The first step in […]

How We Treat Left-Sided vs Right-Sided Colon Cancer

Learning Objectives • To understand the biological and clinical differences between left-sided and right-sided colon cancer; • To identify appropriate therapies for patients with metastatic […]

When to Use Triplet Chemotherapy as First-Line Treatment in Metastatic Colorectal Cancer

H&O What are the options for first-line treatment in metastatic colorectal cancer (CRC)? CC First, I want to emphasize that chemotherapy still matters a great […]

Immunotherapy in Colorectal Cancer With Mismatch Repair Deficiency

H&O Which immunotherapy agents have been approved for use in colorectal cancer (CRC) with mismatch repair deficiency (MMR-D)? MO We have a choice of 3 […]

Optimal Duration of Adjuvant Therapy for Stage III Colon Cancer

Abstract: Colon cancer remains a major cause of mortality worldwide. Following adequate surgical resection of lymph node–positive colon cancer, the standard of care since 2004 […]

How Should BRAF V600E–Mutated Colorectal Cancer Be Treated?

H&O How common is the BRAF V600E mutation in colorectal cancer (CRC), and how does it affect prognosis? SK The BRAF V600E mutation is present […]

How I Treat Chemorefractory Metastatic Colorectal Cancer

Learning Objectives • Identify the most appropriate systemic therapies for patients with chemorefractory metastatic colorectal cancer • Determine the role of molecular sequencing in identifying […]

Immunotherapy in Colorectal Cancer

H&O Is colorectal cancer (CRC) a good target for immunotherapy? DL A subset of patients with CRC have tumors that are found to be deficient […]