Development of Poly(ADP-Ribose) Polymerase Inhibitors in the Treatment of BRCA-Mutated Breast Cancer

Abstract: The poly(ADP-ribose) polymerases (PARPs) 1 and 2 are DNA-binding enzymes that play a critical role in the repair of DNA. The use of PARP […]

The Evolution of Poly(ADP-Ribose) Polymerase Inhibitors in the Treatment of Breast Cancer

H&O Could you describe the indications for olaparib that have been added since it was first approved? SD The poly(ADP-ribose) polymerase (PARP) inhibitor olaparib (Lynparza, […]