New Targets in Endocrine-Resistant Hormone Receptor–Positive Breast Cancer

Abstract: Endocrine-based treatments are the backbone of initial therapy for advanced hormone receptor–positive breast cancers. Developing new therapeutic strategies to address resistance to endocrine therapy is […]

Reversing Resistance to Checkpoint Inhibitors and Targeted Therapy in Metastatic Melanoma

  H&O  How often do patients with metastatic melanoma experience primary or secondary resistance to checkpoint inhibitors? MS  An estimated 40% to 50% of patients with […]

Molecular Pathways and Targeted Therapy in Cholangiocarcinoma

  Abstract: Cholangiocarcinoma (CCA) encompasses a rare group of malignancies arising from epithelial cells lining the biliary tree that connects the liver and gallbladder to the […]