Category: Colorectal Cancer
The Emergence of Targetable Pathways in Colorectal Cancer
Abstract: Colorectal cancer continues to be one of the leading causes of cancer-related morbidity and mortality globally. Despite an overall decreasing incidence of the disease, early-onset […]
Total Neoadjuvant Therapy Approach in Rectal Adenocarcinoma
Abstract: The treatment of locally advanced rectal cancer has improved over the years owing to advancements in surgical techniques and chemoradiation, developing into a multidisciplinary approach […]
Determining the Optimal Duration of Adjuvant Therapy in Colon Cancer
H&O Which patients with colon cancer are eligible for adjuvant therapy? JM Patients with colon cancer are eligible for adjuvant therapy if they have stage III […]
Circulating Tumor DNA as a Marker of Minimal Residual Disease in Colorectal Cancer
H&O How common is recurrence after surgery for nonmetastatic colon cancer? SK Most patients with stage II or III colon cancer have a risk for […]
EGFR Inhibition in Colorectal Cancer With Liver Metastasis
H&O What is the standard course of treatment for patients with metastatic colorectal cancer that has spread to the liver? AG The first step in […]
How We Treat Left-Sided vs Right-Sided Colon Cancer
Learning Objectives • To understand the biological and clinical differences between left-sided and right-sided colon cancer; • To identify appropriate therapies for patients with metastatic […]
The Role of HIPEC in Patients With Advanced Colorectal Cancer
H&O Which patients with colorectal cancer are eligible for treatment with HIPEC? Dr Bartlett Intraperitoneal hyperthermic chemoperfusion (HIPEC) is appropriate for certain patients with colorectal […]
The Role of Comprehensive Molecular Profiling in Colorectal Cancer
H&O What are the relevant mutations or other alterations that molecular profiling can pick up in colorectal cancer, and how common are they? HH The […]
When to Use Triplet Chemotherapy as First-Line Treatment in Metastatic Colorectal Cancer
H&O What are the options for first-line treatment in metastatic colorectal cancer (CRC)? CC First, I want to emphasize that chemotherapy still matters a great […]
Immunotherapy in Colorectal Cancer With Mismatch Repair Deficiency
H&O Which immunotherapy agents have been approved for use in colorectal cancer (CRC) with mismatch repair deficiency (MMR-D)? MO We have a choice of 3 […]
Optimal Duration of Adjuvant Therapy for Stage III Colon Cancer
Abstract: Colon cancer remains a major cause of mortality worldwide. Following adequate surgical resection of lymph node–positive colon cancer, the standard of care since 2004 […]
The Role of HER2 Amplification Testing in Metastatic Colorectal Cancer
H&O How common is human epidermal growth factor receptor 2 (HER2) amplification in metastatic colorectal cancer (mCRC)? KR HER2 amplification is found in approximately 3% […]
Microsatellite Instability in Colorectal Cancer: Overview of Its Clinical Significance and Novel Perspectives
Abstract: Microsatellite instability (MSI) is a key biomarker in colorectal cancer (CRC), with crucial diagnostic, prognostic, and predictive implications. Testing for mismatch repair deficiency (MMR-D)/MSI […]
A Closer Look at Regorafenib
Regorafenib (Stivarga, Bayer) is a once-daily, oral multikinase inhibitor. It first received approval in September 2012 for patients with metastatic colorectal cancer (CRC) who were […]
Chemoprevention of Colorectal Cancer: Aspirin and Beyond
H&O What is the most effective approach to preventing colorectal cancer (CRC)? PL As America’s population reaching age 50 years expands, there is an urgent […]
How Should BRAF V600E–Mutated Colorectal Cancer Be Treated?
H&O How common is the BRAF V600E mutation in colorectal cancer (CRC), and how does it affect prognosis? SK The BRAF V600E mutation is present […]
How I Treat Chemorefractory Metastatic Colorectal Cancer
Learning Objectives • Identify the most appropriate systemic therapies for patients with chemorefractory metastatic colorectal cancer • Determine the role of molecular sequencing in identifying […]
Immunotherapy in Colorectal Cancer
H&O Is colorectal cancer (CRC) a good target for immunotherapy? DL A subset of patients with CRC have tumors that are found to be deficient […]
What Is the Optimal Duration of Adjuvant Therapy in Colon Cancer?
H&O Which patients with colon cancer require adjuvant therapy? AS Patients who are considered to be at high risk for recurrence require adjuvant therapy. This […]
Locoregional Therapy for Liver Metastases in Colorectal Cancer
H&O How often does colorectal cancer (CRC) metastasize to the liver? AK The exact frequency has been controversial for a long time. Current data suggest […]