The Role of CTLA-4 Inhibition in Immunotherapy for MSI-H/dMMR Metastatic Colorectal Cancer

H&O When is immunotherapy used in microsatellite instability–high/mismatch repair–deficient (MSI-H/dMMR) metastatic colorectal cancer (mCRC)? CW Immunotherapy is used for patients with mCRC whose tumors test positive […]

Liver Transplant in Patients With Metastatic Colorectal Cancer

H&O How common are liver-limited metastases in colorectal cancer (CRC)? BA Approximately one-third of patients with metastatic CRC (mCRC) have metastases that are isolated to the […]

The Emergence of Targetable Pathways in Colorectal Cancer

Abstract: Colorectal cancer continues to be one of the leading causes of cancer-related morbidity and mortality globally. Despite an overall decreasing incidence of the disease, early-onset […]

Total Neoadjuvant Therapy Approach in Rectal Adenocarcinoma

Abstract: The treatment of locally advanced rectal cancer has improved over the years owing to advancements in surgical techniques and chemoradiation, developing into a multidisciplinary approach […]

Determining the Optimal Duration of Adjuvant Therapy in Colon Cancer

H&O Which patients with colon cancer are eligible for adjuvant therapy? JM Patients with colon cancer are eligible for adjuvant therapy if they have stage III […]

Circulating Tumor DNA as a Marker of Minimal Residual Disease in Colorectal Cancer

H&O How common is recurrence after surgery for nonmetastatic colon cancer? SK Most patients with stage II or III colon cancer have a risk for […]

EGFR Inhibition in Colorectal Cancer With Liver Metastasis

H&O What is the standard course of treatment for patients with metastatic colorectal cancer that has spread to the liver? AG The first step in […]

How We Treat Left-Sided vs Right-Sided Colon Cancer

Learning Objectives • To understand the biological and clinical differences between left-sided and right-sided colon cancer; • To identify appropriate therapies for patients with metastatic […]

The Role of HIPEC in Patients With Advanced Colorectal Cancer

H&O Which patients with colorectal cancer are eligible for treatment with HIPEC? Dr Bartlett Intraperitoneal hyperthermic chemoperfusion (HIPEC) is appropriate for certain patients with colorectal […]

The Role of Comprehensive Molecular Profiling in Colorectal Cancer

H&O What are the relevant mutations or other alterations that molecular profiling can pick up in colorectal cancer, and how common are they? HH The […]

When to Use Triplet Chemotherapy as First-Line Treatment in Metastatic Colorectal Cancer

H&O What are the options for first-line treatment in metastatic colorectal cancer (CRC)? CC First, I want to emphasize that chemotherapy still matters a great […]

Immunotherapy in Colorectal Cancer With Mismatch Repair Deficiency

H&O Which immunotherapy agents have been approved for use in colorectal cancer (CRC) with mismatch repair deficiency (MMR-D)? MO We have a choice of 3 […]

Optimal Duration of Adjuvant Therapy for Stage III Colon Cancer

Abstract: Colon cancer remains a major cause of mortality worldwide. Following adequate surgical resection of lymph node–positive colon cancer, the standard of care since 2004 […]

The Role of HER2 Amplification Testing in Metastatic Colorectal Cancer

H&O How common is human epidermal growth factor receptor 2 (HER2) amplification in metastatic colorectal cancer (mCRC)? KR HER2 amplification is found in approximately 3% […]

Microsatellite Instability in Colorectal Cancer: Overview of Its Clinical Significance and Novel Perspectives

Abstract: Microsatellite instability (MSI) is a key biomarker in colorectal cancer (CRC), with crucial diagnostic, prognostic, and predictive implications. Testing for mismatch repair deficiency (MMR-D)/MSI […]

A Closer Look at Regorafenib

Regorafenib (Stivarga, Bayer) is a once-daily, oral multikinase inhibitor. It first received approval in September 2012 for patients with metastatic colorectal cancer (CRC) who were […]

Chemoprevention of Colorectal Cancer: Aspirin and Beyond

H&O What is the most effective approach to preventing colorectal cancer (CRC)? PL As America’s population reaching age 50 years expands, there is an urgent […]

How Should BRAF V600E–Mutated Colorectal Cancer Be Treated?

H&O How common is the BRAF V600E mutation in colorectal cancer (CRC), and how does it affect prognosis? SK The BRAF V600E mutation is present […]

How I Treat Chemorefractory Metastatic Colorectal Cancer

Learning Objectives • Identify the most appropriate systemic therapies for patients with chemorefractory metastatic colorectal cancer • Determine the role of molecular sequencing in identifying […]

Immunotherapy in Colorectal Cancer

H&O Is colorectal cancer (CRC) a good target for immunotherapy? DL A subset of patients with CRC have tumors that are found to be deficient […]