The Emerging Use of Chemotherapy-Free Regimens in Adults With Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia

Abstract: Before the development of tyrosine kinase inhibitors (TKIs), the outcome of patients with a diagnosis of Philadelphia chromosome (Ph)–positive acute lymphoblastic leukemia was dismal. Combinations […]

A Review of Essential Thrombocythemia and Its Complications

Abstract: Essential thrombocythemia (ET) is a chronic myeloproliferative neoplasm characterized by an increased platelet count in the peripheral blood and excessive megakaryopoiesis in the bone marrow. […]

Immunotherapy Treatment Landscape for Patients With Endometrial Cancer: Current Evidence and Future Opportunities

Abstract: Endometrial cancer is the most common gynecologic cancer in the United States, with a rising incidence and mortality. Traditionally, systemic treatment has included combination platinum- […]

Treatment Landscape of Advanced High-Grade Neuroendocrine Neoplasms

Abstract: Grade 3 neuroendocrine neoplasms (NEN G3) are high-grade (Ki-67 index >20%) neuroendocrine malignancies that comprise both rapidly proliferating, well-differentiated neuroendocrine tumors (NET G3) and poorly […]

Ongoing Progress in BRAF-Mutated Non–Small Cell Lung Cancer

Abstract: Activating BRAF mutations are detected in 1.5% to 4.5% of patients with non–small cell lung cancer (NSCLC). These mutations involve the mitogen-activated protein kinase/extracellular signal-regulated […]

The Role of Cytoreductive Surgery and Intraperitoneal Chemotherapy in Gastric Cancer

Abstract: Gastric cancer (GC) with peritoneal carcinomatosis (PC) progresses rapidly and has historically dismal survival rates. Given the aggressive tumor biology and poor survival outcomes of […]

Treatment of Amyloid Light Chain Cardiac Amyloidosis: Systematic Review and Future Directions

Abstract: Background: Several treatment strategies for amyloid light chain cardiac amyloidosis (AL-CA) have been described in the literature; however, there is no consensus about the optimal […]

Current and Emerging Options for Patients With Melanoma Brain Metastases

Abstract: Melanoma is the most aggressive skin cancer, with a high incidence of metastatic spread and a predilection for metastases to the brain. It represents the […]

How We Manage Idiopathic Multicentric Castleman Disease

Overview • We recommend first-line treatment with anti–interleukin 6 (anti–IL-6) for all patients with idiopathic multicentric Castleman disease. • We recommend enrollment of all patients with […]

A Narrative Review of Anti–SARS-CoV-2 Vaccines and Immune Thrombocytopenia: Be Aware, But Reassured

Abstract: Background: The COVID-19 pandemic gave rise to rapid development of anti–SARS-CoV-2 vaccines using established and new technologies. Immune thrombocytopenia (ITP) is a bleeding disorder that […]

Hematologic Concerns in Transgender Patients

Abstract: Patients with gender dysphoria are increasingly seeking gender-affirming therapies, which can have adverse hematologic effects. For example, estrogen can increase the risk for arterial and […]

New Treatment Strategies for Waldenström Macroglobulinemia

Abstract: The development of high-throughput technologies has allowed us to characterize the molecular landscape of hematologic neoplasms and identify somatic mutations. As a result, we can […]

JAK Inhibitors in the Treatment of Myelofibrosis

Abstract: Myelofibrosis (MF) is a myeloproliferative neoplasm driven by constitutive activation of the JAK/STAT pathway, resulting in clonal hematopoiesis, fibrotic replacement of the bone marrow, extramedullary […]

The Role of Circulating Tumor DNA in Evaluating Minimal Residual Disease in Luminal Gastrointestinal Malignancies

Abstract: The analysis of circulating tumor DNA (ctDNA) has multiple uses in oncology. In the past few years, studies with varying designs, methods, and quality have […]

Clonal Cytopenias of Undetermined Significance: Potential Predictor of Myeloid Malignancies?

Abstract: The recent identification of the potential for clonal replication in patients with unexplained cytopenias, resulting in myelodysplastic syndrome (MDS) or myeloid malignancies, has opened the […]

Follicular Lymphoma Grade 3: A Comprehensive Review

Abstract: Follicular lymphoma (FL) is a heterogeneous entity with disparate outcomes based on clinical and pathologic characteristics. An increasingly detailed understanding of high-grade FL (grade 3) […]

CAR T-Cell Therapy for Relapsed/Refractory Non-Hodgkin’s Lymphoma: A Comprehensive Review

Abstract: Non-Hodgkin lymphoma (NHL) is the seventh most common type of malignancy worldwide, with approximately 544,000 cases diagnosed in 2020.1-3 The vast majority of NHLs are […]

Systemic Management of Brain Metastases in HER2+ Breast Cancer in 2022

Abstract: Up to half of all patients with metastatic human epidermal growth factor receptor 2–positive (HER2+) breast cancer will eventually acquire brain metastases (BrMs), which are […]

Radiation Therapy and Immunotherapy in Locally Advanced NSCLC

H&O What is standard treatment in locally advanced non–small cell lung cancer (NSCLC)? PL Standard treatment in locally advanced NSCLC used to be 6 weeks of […]

Management of Acute Lymphoblastic Leukemia in Older Adults

Abstract: Acute lymphoblastic leukemia, commonly known to affect the younger population, is a disease that is affecting the elderly in an increasing amount as the human […]