Evolving Standards of Care for Neoadjuvant and Adjuvant Therapy in Esophageal, Gastroesophageal Junction, and Gastric Cancer

Abstract: Multimodality therapy, which can include systemic therapy, radiation therapy, and surgery, is the preferred approach for most localized, clinical T2 to T4, and/or node-positive esophageal, […]

Biomarkers for Immune Therapy in Gastrointestinal Cancers

Abstract: Immunotherapy with checkpoint blockade of pro-grammed death 1 (PD-1) and cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) has substantially increased the number of anticancer agents in […]

The Role of Radiation Therapy in Upper Gastrointestinal Cancers

Abstract: Upper gastrointestinal cancers are common and account for a high proportion of cases of cancer-related morbidity and mortality. Combined-modality therapy with surgery, chemotherapy, and […]

Molecular Biology of Gastroesophageal Cancers: Opportunities and Challenges

Abstract: Gastroesophageal (GE) malignancies make up a significant and growing segment of newly diagnosed cancers. Approximately 80% of patients who have GE cancers die within […]