Diagnosis and Management of Dysfibrinogenemia

H&O What is dysfibrinogenemia, and how common is it? SS Dysfibrinogenemia is a qualitative functional disorder of fibrinogen. It is characterized in the laboratory by […]

New and Experimental Agents for Sickle Cell Disease

H&O What treatments are available for patients with sickle cell disease? KA Sickle cell disease (SCD) can be cured with allogeneic hematopoietic stem cell transplant. […]

Current Approaches to Pregnancy and Childbirth in Women With von Willebrand Disease

H&O How common is von Willebrand disease (VWD)? JJ VWD is the most common inherited bleeding disorder, with an incidence of approximately 1 per 1000 […]

Are Direct Acting Oral Anticoagulants Ready for Prime-Time Use in Cancer-Related Thrombosis?

H&O How common is thrombosis in patients being treated for cancer? MS Approximately 20% to 25% of patients with venous thromboembolism (VTE) at a typical […]

Myelofibrosis: Clinicopathologic Features, Prognosis, and Management

Abstract: Myelofibrosis is one of the BCR-ABL–negative clonal disorders that collectively are known as myeloproliferative neoplasms (MPNs). It is caused by the proliferation of clonal […]

Should Autologous Platelet-Rich Plasma Be Used in Patients With Hematologic Disease?

H&O What is autologous platelet-rich plasma, and how is it prepared? AMC More than 30 years ago, Knighton and colleagues studied 49 patients with chronic, nonhealing cutaneous ulcers—including […]

New Guidelines From the NCCN for Polycythemia Vera

H&O What is polycythemia vera? RM Polycythemia vera is a myeloproliferative neoplasm. There are approximately 150,000 patients with polycythemia vera in the United States. The […]

Current Challenges in the Management of Essential Thrombocythemia

Abstract: Essential thrombocythemia (ET), an uncommon blood cancer, is one of the classic myeloproliferative neoplasms, a category that also includes polycythemia vera and primary myelofibrosis. […]

Polycythemia Vera: From New, Modified Diagnostic Criteria to New Therapeutic Approaches

Abstract: Polycythemia vera (PV) is a Philadelphia chromosome–negative chronic myeloproliferative neoplasm that is associated with a Janus kinase 2 (JAK2) mutation in most cases. The […]

The Role of D-dimer Testing in Clinical Hematology and Oncology

H&O What is D dimer? CG D dimer is a specific antigen derived from the degradation of factor XIIIa cross-linked fibrin. Monoclonal antibodies specific for […]

New Insights Into Cytomegalovirus Infection After Allogeneic Hematopoietic Stem Cell Transplant

H&O How common is CMV infection among patients undergoing allogeneic hematopoietic stem cell transplant? MB Cytomegalovirus (CMV) reactivation occurs in approximately 50% to 70% of […]

Antifibrinolytic Agents in Acquired Bleeding Disorders

H&O What are the main causes of acquired coagulopathy? MW We categorize these based on what can go wrong along the many pathways of coagulation: […]

Prevention and Management of Thrombosis in Myeloproliferative Neoplasms

H&O What are the various myeloproliferative neoplasms (MPNs)? MK The conventional BCR-ABL–negative MPN categories are polycythemia vera (PV), essential thrombocythemia (ET), myelofibrosis, unclassified MPN (MPN-U), chronic […]

Manifestations and Management of Veno-occlusive Disease/Sinusoidal Obstruction Syndrome in the Era of Contemporary Therapies

Abstract: The concept of veno-occlusive disease (VOD), along with our understanding of it, has historically been and remains an evolving phenomenon. This review presents a […]

Superficial Vein Thrombosis: New Perspectives and Observations From Recent Clinical Trials

H&O What is superficial vein thrombosis, and how common is it? BC Superficial vein thrombosis (SVT) is the preferred term to indicate thrombosis of any […]

What Hematologists Need to Know About Acute Hepatic Porphyria

H&O What is porphyria? MB The porphyrias encompass a group of inherited metabolic disorders that result from a deficiency of one of the enzymes in the […]

Zika and the Safety of the US Blood Supply

H&O What exactly is the Zika virus, and when was it discovered? MB The Zika virus was discovered in 1947 in the Zika Forest of […]

The Mediterranean Diet in Hypercoagulable States and Cancer

H&O What are the characteristics of the Mediterranean diet? MM The traditional Mediterranean diet refers to the dietary pattern that was typical until the mid-1960s of […]

Prevention and Treatment of Stroke in Patients With Sickle Cell Disease

H&O What types of stroke occur in people with sickle cell anemia (SCA)? AK Overt strokes occur in approximately 5% to 10% of children with sickle […]