Recent Approval of Pirtobrutinib for Mantle Cell Lymphoma

H&O What is pirtobrutinib and how does it work? JC Pirtobrutinib (Jaypirca, Lilly) is a recently approved therapy for patients with relapsed or refractory mantle cell […]

Measurable Residual Disease in Acute Lymphoblastic Leukemia: Techniques and Therapeutic Utility

H&O Is testing for measurable residual disease (MRD) now a standard component of management of patients with acute lymphoblastic leukemia (ALL)? LM Measurement of MRD is […]

The Evolving Use of CAR T-Cell Therapy in Follicular Lymphoma

H&O What clinical trial data led to the approval of chimeric antigen receptor (CAR) T-cell therapy in follicular lymphoma? LN In March 2021, the US Food […]

IDH Inhibitors in Acute Myeloid Leukemia and Myelodysplastic Syndrome

H&O How common are isocitrate dehydrogenase (IDH) mutations in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)? ES At diagnosis, approximately 20% to 25% […]

Chimeric Antigen Receptor T-Cell Therapy Targeting CD30 in Hodgkin Lymphoma

H&O What prompted your research of chimeric antigen receptor (CAR) T-cell therapy in Hodgkin lymphoma? BS It has been known for a long time that Hodgkin […]

Chimeric Antigen Receptor Natural Killer Cells for the Treatment of Patients With B-Cell Malignancies

H&O What are the outcomes associated with chimeric antigen receptor (CAR) T-cell therapy in patients with non-Hodgkin lymphoma (NHL) or chronic lymphocytic leukemia (CLL)? KR […]

Optimizing Administration of CAR T-Cell Therapy During the COVID-19 Pandemic

H&O What are the goals of the CAR T-Cell Consortium? MB The initial aim of the CAR T-Cell Consortium was to evaluate real-world experience with […]

Improving Outcomes With Checkpoint Blockade in Non-Hodgkin Lymphoma

H&O How effective are standard treatments for non-Hodgkin lymphoma (NHL)? JB There are effective therapies for diffuse large B-cell lymphoma (DLBCL), which is the most […]

Insights Into Survivorship Care for Cancer Patients

H&O Approximately how many people in the United States are survivors of cancer? KSB Currently, an estimated 18 to 20 million people in the United […]

Proactive Steps to Optimize the Management of Polycythemia Vera and Myelofibrosis

H&O What are the management goals for polycythemia vera? RM The first goal is to control hematocrit levels and avoid erythrocytosis to decrease the likelihood […]