Category: Hematology
Bleeding Complications With Bruton Tyrosine Kinase Inhibitors
H&O What types of bleeding complications can occur with Bruton tyrosine kinase (BTK) inhibitors? TD Bleeding complications are very common and can range from minor “nuisance” […]
Thrombosis With Thrombocytopenia Syndrome After COVID-19 Vaccination
H&O What types of blood clotting issues are being seen in people after COVID vaccination? AC We are seeing both venous and arterial thromboembolic events. A […]
The Use of Telemedicine in Hematology and Oncology
H&O What exactly does telemedicine encompass? WW Telemedicine can include a variety of components of health care delivered virtually. Since the beginning of the pandemic last […]
Highlights in COVID-19 From the 62nd American Society of Hematology Annual Meeting
Highlights in COVID-19 From the 62nd American Society of Hematology Annual Meeting December 5-8, 2020, Virtual The high incidence of venous thromboembolism (VTE) and its consequent […]
Transfusion Replacement Strategies in Jehovah’s Witnesses and Others Who Decline Blood Products
Abstract: The use of blood transfusions is a mainstay of modern medical practice. Jehovah’s Witnesses decline the use of blood transfusions as a matter of faith, […]
New Paradigms for Anticoagulation in Pregnant Women With Inherited Thrombophilia
H&O How common is inherited thrombophilia among women of childbearing age, and how often does it lead to venous thromboembolism? DA The term thrombophilia is […]
Updated Recommendations for the Treatment of Immune Thrombocytopenia
H&O Briefly, what is immune thrombocytopenia? JC Immune thrombocytopenia (ITP) is an immunologically mediated bleeding disorder in which autoantibodies against platelet antigens cause premature platelet […]
COVID-19 and Hypercoagulability
H&O What are the manifestations of COVID-19 that relate to coagulation? MS The manifestations of coronavirus disease 2019 (COVID-19) that relate to coagulation appear to […]
Defining Treatment Duration in Atypical Hemolytic Uremic Syndrome in Adults: A Clinical and Pathological Approach
Abstract: Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy (TMA) that is driven by uncontrolled activation of the alternative complement pathway, classically in the […]
Highlights in Nonmalignant Hematology From the 2019 American Society of Hematology Meeting
December 7-10, 2019, Orlando, Florida Complement Inhibition Shows Promise in Autoimmune Hematologic Disorders Two recent studies support the use of sutimlimab, an investigational inhibitor of […]
Cold Agglutinin Disease: Where Do We Stand, and Where Are We Going?
Abstract: Primary cold agglutinin disease (CAD) is characterized by a very indolent bone marrow clonal B-cell lymphoproliferative disorder that initiates an autoimmune hemolytic anemia. The […]
The Use of Direct Oral Anticoagulants in Antiphospholipid Syndrome
H&O What is antiphospholipid syndrome, and what causes it? HC Antiphospholipid syndrome (APS) is an acquired autoimmune thrombophilia that is characterized by thrombosis and/or pregnancy […]
Update on Transfusion-Related Acute Lung Injury
H&O How did you become interested in transfusion-related acute lung injury? PT I became interested in transfusion-related acute lung injury (TRALI) in 2002 when a […]
Diagnosis and Treatment of Hemophilia
Abstract: Hemophilia A and B are inherited bleeding disorders characterized by deficiency or dysfunction of coagulation protein factors VIII and IX, respectively. Recurrent joint and […]
How I Treat Cold Agglutinin Hemolytic Anemia
Overview • Cold agglutinin disease is an immune-mediated hemolytic anemia characterized by complement on the red cell surface. • In half of patients, observation is […]
Antiplatelet Agents for Preventing Vaso-occlusive Events in People With Sickle Cell Disease: A Systematic Review
Abstract: Background: Sickle cell disease (SCD) is the most common hemoglobinopathy, occurring worldwide, and vaso-occlusive events (VOEs) are its paramount, hallmark clinical manifestation. Evidence exists […]
Diagnosis and Treatment of Cold Agglutinin Disease
H&O How common is cold agglutinin disease? CR Cold agglutinin disease is rare, with an estimated incidence of approximately 1 per million. H&O What causes […]
Diagnosing or Ruling Out Polycythemia Vera in Patients With Erythrocytosis
H&O How is erythrocytosis defined? JP Erythrocytosis is the presence of too many red blood cells. Several different parameters are used to diagnose erythrocytosis in […]
New Paradigms and Therapies for Iron Replacement in Iron Deficiency Anemia
H&O Who is a candidate for iron replacement? MA Anyone who is iron deficient is a candidate for iron replacement. Examples include women who are […]
Immune-Mediated Hemolytic Anemia and Thrombocytopenia in Clonal B-Cell Disorders: A Review
Abstract: Autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia purpura (ITP) have been associated with B-cell lymphoproliferative disorders. Here, we review the epidemiology, pathogenesis, diagnosis, and […]