Should Autologous Platelet-Rich Plasma Be Used in Patients With Hematologic Disease?

  H&O  What is autologous platelet-rich plasma, and how is it prepared? AMC  More than 30 years ago, Knighton and colleagues studied 49 patients with chronic, nonhealing cutaneous ulcers—including […]

New Guidelines From the NCCN for Polycythemia Vera

  H&O  What is polycythemia vera? RM  Polycythemia vera is a myeloproliferative neo­plasm. There are approximately 150,000 patients with poly­cythemia vera in the United States. The […]

Current Challenges in the Management of Essential Thrombocythemia

  Abstract: Essential thrombocythemia (ET), an uncommon blood cancer, is one of the classic myeloproliferative neoplasms, a category that also includes polycythemia vera and primary myelofibrosis. […]

Polycythemia Vera: From New, Modified Diagnostic Criteria to New Therapeutic Approaches

  Abstract: Polycythemia vera (PV) is a Philadelphia chromosome–negative chronic myeloproliferative neoplasm that is associated with a Janus kinase 2 (JAK2) mutation in most cases. The […]

The Role of D-dimer Testing in Clinical Hematology and Oncology

  H&O  What is D dimer? CG  D dimer is a specific antigen derived from the degradation of factor XIIIa cross-linked fibrin. Monoclonal antibodies specific for […]

New Insights Into Cytomegalovirus Infection After Allogeneic Hematopoietic Stem Cell Transplant

  H&O  How common is CMV infection among patients undergoing allogeneic hematopoietic stem cell transplant? MB Cytomegalovirus (CMV) reactivation occurs in approximately 50% to 70% of […]

Antifibrinolytic Agents in Acquired Bleeding Disorders

  H&O  What are the main causes of acquired coagulopathy? MW  We categorize these based on what can go wrong along the many pathways of coagulation: […]

Prevention and Management of Thrombosis in Myeloproliferative Neoplasms

H&O  What are the various myeloproliferative neoplasms (MPNs)? MK  The conventional BCR-ABL–negative MPN cat­egories are polycythemia vera (PV), essential throm­bocythemia (ET), myelofibrosis, unclassified MPN (MPN-U), chronic […]

Manifestations and Management of Veno-occlusive Disease/Sinusoidal Obstruction Syndrome in the Era of Contemporary Therapies

  Abstract: The concept of veno-occlusive disease (VOD), along with our understanding of it, has historically been and remains an evolving phenomenon. This review presents a […]

Superficial Vein Thrombosis: New Perspectives and Observations From Recent Clinical Trials

  H&O  What is superficial vein thrombosis, and how common is it? BC  Superficial vein thrombosis (SVT) is the preferred term to indicate thrombosis of any […]

What Hematologists Need to Know About Acute Hepatic Porphyria

H&O  What is porphyria? MB The porphyrias encompass a group of inherited metabolic disorders that result from a deficiency of one of the enzymes in the […]

Zika and the Safety of the US Blood Supply

  H&O  What exactly is the Zika virus, and when was it discovered? MB The Zika virus was discovered in 1947 in the Zika Forest of […]

The Mediterranean Diet in Hypercoagulable States and Cancer

H&O What are the characteristics of the Mediterranean diet? MM The traditional Mediterranean diet refers to the dietary pattern that was typical until the mid-1960s of […]

Prevention and Treatment of Stroke in Patients With Sickle Cell Disease

H&O What types of stroke occur in people with sickle cell anemia (SCA)? AK Overt strokes occur in approximately 5% to 10% of children with sickle […]