Risk Factors for Disease Progression and Treatment Goals in Polycythemia Vera

Abstract: Polycythemia vera is a Philadelphia chromosome–negative myeloproliferative neoplasm characterized by the clonal proliferation of hematopoietic cells, leading to the overproduction of erythrocytes and the elaboration […]

Cases in the Management of Polycythemia Vera: A Patient With Progressive Leukocytosis

Patient Case A 57-year-old man presented with complaints of headaches, dizziness, hyperhidrosis, pruritus, and early satiety (Table 1). On examination, he had mild facial and palmar […]

Cases in the Management of Polycythemia Vera: The Importance of Strict Hematocrit Control

Case 2 of a 3-Part Series Patient Case  A 68-year-old man presented with elevated levels of hemoglobin and hematocrit, as well as an elevated platelet count […]

Cases in the Management of Polycythemia Vera: Switching From Hydroxyurea to Ruxolitinib to Resolve Symptoms and Improve Quality of Life 

Case 1 of a 3-Part Series Patient Case A 65-year-old man was diagnosed with polycythemia vera (PV) 3 years ago (Table 1). He initially presented with […]

Proactive Steps to Optimize the Management of Polycythemia Vera and Myelofibrosis

  H&O  What are the management goals for polycythemia vera? RM  The first goal is to control hematocrit levels and avoid erythrocytosis to decrease the likelihood […]

The Evolving Understanding of Prognosis in Post–Essential Thrombocythemia Myelofibrosis and Post–Polycythemia Vera Myelofibrosis vs Primary Myelofibrosis

  Abstract: Myelofibrosis (MF) is the most aggressive of the classic Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs). In some patients with essential thrombocytopenia or polycythemia vera, which […]

Diagnosing or Ruling Out Polycythemia Vera in Patients With Erythrocytosis

  H&O  How is erythrocytosis defined?  JP  Erythrocytosis is the presence of too many red blood cells. Several different parameters are used to diagnose erythrocytosis in […]

Novel Therapeutic Approaches in Polycythemia Vera

  Abstract:  Polycythemia vera (PV) is the most common Philadelphia chromosome–negative myeloproliferative neoplasm. Whereas low-risk patients are treated with aspirin and phlebotomy, high-risk patients receive cytoreductive […]

New Guidelines From the NCCN for Polycythemia Vera

  H&O  What is polycythemia vera? RM  Polycythemia vera is a myeloproliferative neo­plasm. There are approximately 150,000 patients with poly­cythemia vera in the United States. The […]

Polycythemia Vera: From New, Modified Diagnostic Criteria to New Therapeutic Approaches

  Abstract: Polycythemia vera (PV) is a Philadelphia chromosome–negative chronic myeloproliferative neoplasm that is associated with a Janus kinase 2 (JAK2) mutation in most cases. The […]