Category: Advances in LLM
Epcoritamab, a Promising Therapy for Richter Syndrome?
H&O What defines Richter syndrome? AK Richter syndrome (RS), also known as Richter transformation, refers to the development of an aggressive lymphoma in the setting of […]
The Use of Glofitamab in Relapsed Diffuse Large B-Cell Lymphoma
H&O What is glofitamab, and how does it work for patients with relapsed and refractory (R/R) diffuse large B-cell lymphoma (DLBCL)? LF Glofitamab (Columvi, Genentech) is […]
Update on the CAPTIVATE Trial of Ibrutinib Plus Venetoclax
H&O Could you describe the impetus for and design of the CAPTIVATE trial? TS The large, multicenter, phase 2 CAPTIVATE trial focused on patients with chronic […]
Mosunetuzumab, the First Bispecific Approved for Follicular Lymphoma
H&O What is mosunetuzumab (Lunsumio, Genentech) and how does it work? LEB Mosunetuzumab is a bispecific antibody-based T-cell engager with 2 binding sites. Unlike conventional monoclonal […]
Is Blinatumomab Now Standard of Care Consolidation for Patients With ALL?
H&O What is blinatumomab and how does it work in treating acute lymphocytic leukemia (ALL)? SL Blinatumomab (Blincyto, Amgen), which is classified as a bispecific antibody, […]
Quizartinib, the Next FLT3 Inhibitor
H&O What are FMS-like tyrosine kinase 3 (FLT3) inhibitors, and how have they affected the treatment of patients with acute myeloid leukemia (AML)? JC FLT3 mutations […]
Momelotinib, the Next JAK2 Inhibitor?
H&O What is momelotinib and how does it work? LM Momelotinib is a selective inhibitor of Janus kinase 1 (JAK1), JAK2, and activin A receptor type […]
Zandelisib and B-Cell Lymphomas
H&O How does zandelisib work? AZ Zandelisib is a phosphoinositide 3-kinase delta (PI3K-δ) inhibitor with a long half-life. PI3K comes in multiple isoforms, including alpha, beta, […]
Noncovalent BTK Inhibitors in B-Cell Lymphoma
H&O What are the limitations of standard (covalent) BTK inhibitors in B-cell malignancies? CC The 2 major limitations of covalent Bruton’s tyrosine kinase (BTK) inhibitors are […]
Optimizing the Benefits of BCMA-Targeted CAR T-Cell Therapy in Multiple Myeloma
H&O Why is the B-cell maturation antigen (BCMA) a good target for chimeric antigen receptor (CAR) T-cell therapy in multiple myeloma? SL BCMA is an important […]
Targeting the Microbiome to Improve Outcomes in Stem Cell Transplant
H&O What are the characteristics of a healthy microbiome? DP A healthy microbiome is dynamic and diverse. It consists of many different types of commensal bacteria—predominantly […]
Key Points From the SHINE Trial in Mantle Cell Lymphoma
H&O Could you provide some background on mantle cell lymphoma? JT Mantle cell lymphoma is an uncommon type of lymphoma. It represents approximately 6% of non-Hodgkin […]
Advances in the Classification and Management of Patients With T-Cell Lymphoma
H&O What are the most common types of T-cell lymphoma? LP T-cell lymphoma is a heterogeneous group of disorders that encompass many subtypes. T-cell lymphomas that […]
Hyper-CVAD–Based Regimens in Adult Patients With Acute Lymphoblastic Leukemia
H&O How was the hyper-CVAD regimen originally used? EJ The hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD) regimen was developed by Kantarjian and colleagues at MD […]
The Future Role of Bispecific Antibodies in Lymphoma
H&O What is the mechanism of action of bispecific antibodies? JA Bispecific antibodies aim to harness the power of the immune system. These treatments are monoclonal […]
New Approaches to T-Cell Acute Lymphoblastic Leukemia
H&O How common is T-cell acute lymphoblastic leukemia (T-ALL)? DT ALL is uncommon, accounting for approximately 6700 new diagnoses per year in the United States. Between […]
Insights Into the Management of Patients With Primary Central Nervous System Lymphoma
H&O What is the definition of primary central nervous system (CNS) lymphoma ? CF Primary CNS lymphoma is referred to as primary diffuse large B-cell lymphoma […]
Evolving Management of Patients With Double-Hit Lymphoma
H&O What is the definition of double-hit lymphoma? AL Double-hit lymphoma is an aggressive B-cell lymphoma with MYC translocation and a BCL2 and/or BCL6 translocation. The […]
Recent Data for Acalabrutinib in Chronic Lymphocytic Leukemia
H&O What type of drug is acalabrutinib? PG Acalabrutinib (Calquence, AstraZeneca) is a so-called next-generation Bruton’s tyrosine kinase (BTK) inhibitor. The first-generation BTK inhibitor, ibrutinib (Imbruvica, […]
Umbralisib and Ublituximab: An Upcoming Regimen for Chronic Lymphocytic Leukemia
H&O What types of drugs are umbralisib and ublituximab? JG Umbralisib (Ukoniq, TG Therapeutics) is a phosphoinositide 3 (PI3) kinase delta inhibitor. Umbralisib is approved for […]