A Rational Approach to the Development of Drug Combinations in Thoracic Oncology

H&O What is the typical approach to the development of drug combinations in oncology? DRC In clinical trials, drug combinations can reflect several scenarios. A trial […]

Improving the Disclosure of Conflicts of Interest in Medicine

H&O How would you define a conflict of interest? DA In the medical community, a conflict of interest can be defined as a situation in […]

Insights Into the Increasing Costs of Cancer Drugs

H&O How has the price of oncology drugs increased in recent years? PB Introductory prices of cancer drugs have risen more than 100-fold since 1965. […]

Toxicities of Checkpoint Inhibitors: Causes and Management

H&O What are some of the approved checkpoint inhibitors? MP The US Food and Drug Administration (FDA)-approved checkpoint inhibitors fall into 2 broad categories: the […]

Improving the Design of Pivotal Clinical Trials

H&O What are some typical flaws in the design of pivotal clinical trials? VP There are 5 common flaws in the design of pivotal clinical […]

Managing Oncology Drug Costs in a Constrained Environment

H&O How does the National Institute for Health and Care Excellence assign value to drugs and select the ones that will be covered by the […]

Moving From Academia to Industry in the Field of Oncology

H&O What is your background, and why did you switch from academia to industry? JS My commitment to improve the conditions of people with cancer […]

Opportunities for Using Big Data to Advance Cancer Care

H&O Could you please define big data? NM In cancer care, big data commonly refers to a large patient-level data source collected for some other […]

The Role of the NCI Investigational Drug Branch

H&O What is the objective of the Investigational Drug Branch of the National Cancer Institute? JM The National Cancer Institute (NCI) supports promising new drug […]

Ethical Issues in the Development of Oncology Drugs

H&O What are some ethical concerns regarding the typical design of clinical trials in oncology? JK The risk/benefit ratio is an important concern. When treating […]

Dosing Drugs in Elderly Patients With Cancer

H&O What is the rate of cancer in older patients? AH Almost 60% of new cancer diagnoses and 70% of cancer deaths occur in patients older […]

Weight-Based Dosing vs Fixed Dosing of Pembrolizumab: an Economic Analysis

H&O When were the first checkpoint inhibitors approved by the FDA? DG Immunotherapy has been an important breakthrough of the past few years. The cytotoxic […]

Recent and Ongoing Clinical Trials in Glioblastoma

H&O How common is glioblastoma, and what are the symptoms? GL Glioblastoma is the most frequent glioma, and it accounts for the majority of malignant […]

Bayesian Approaches to Evaluating Doses of Drugs

H&O What is Bayes’ theorem? GR Bayes’ theorem is a rule in mathematical probability for computing the probability of an event given that something else […]

Patient-Derived Tumor Xenograft Models in Drug Development

H&O What types of preclinical models are used to predict clinical activity of novel therapies in cancer patients? MH There are now 4 types of […]

Direct-to-Consumer Advertising of Cancer Treatments

H&O What have studies shown about direct-to-consumer advertising of medical treatments? LS A few studies have evaluated direct-to-consumer advertising of medical treatments, but they are […]

The Value in Cancer Care Consortium: Addressing Financial Toxicity

H&O What is the Value in Cancer Care Consortium? AL The Value in Cancer Care Consortium is a group of physicians who have come together […]

Recent Insights Into the Use of Combination Immunotherapy in Solid Tumors

H&O What are the main targets of immunotherapy? JL In solid tumors, immunotherapy currently focuses the most on the checkpoint proteins cytotoxic T-lymphocyte–associated protein 4 […]

How Direct-to-Patient Research Can Improve Interest in Clinical Trials

H&O What are the challenges involved in patient recruitment and retention in traditional clinical trials? DC There are so many challenges. For example, most traditional […]

The Evolving Role of Cyclin-Dependent Kinase Inhibitors in Cancer Management

H&O What is the role of cyclin-dependent kinases, and why are they a target in cancer treatment? GS The cyclin-dependent kinases (CDKs) are a large […]