Bleeding Complications With Bruton Tyrosine Kinase Inhibitors

H&O What types of bleeding complications can occur with Bruton tyrosine kinase (BTK) inhibitors? TD Bleeding complications are very common and can range from minor “nuisance” […]

Thrombosis With Thrombocytopenia Syndrome After COVID-19 Vaccination

H&O What types of blood clotting issues are being seen in people after COVID vaccination? AC We are seeing both venous and arterial thromboembolic events. A […]

The Use of Telemedicine in Hematology and Oncology

H&O What exactly does telemedicine encompass? WW Telemedicine can include a variety of components of health care delivered virtually. Since the beginning of the pandemic last […]

Highlights in COVID-19 From the 62nd American Society of Hematology Annual Meeting

Highlights in COVID-19 From the 62nd American Society of Hematology Annual Meeting December 5-8, 2020, Virtual The high incidence of venous thromboembolism (VTE) and its consequent […]

Transfusion Replacement Strategies in Jehovah’s Witnesses and Others Who Decline Blood Products

Abstract: The use of blood transfusions is a mainstay of modern medical practice. Jehovah’s Witnesses decline the use of blood transfusions as a matter of faith, […]

New Paradigms for Anticoagulation in Pregnant Women With Inherited Thrombophilia

H&O How common is inherited thrombophilia among women of childbearing age, and how often does it lead to venous thromboembolism? DA The term thrombophilia is […]

Updated Recommendations for the Treatment of Immune Thrombocytopenia

H&O Briefly, what is immune thrombocytopenia? JC Immune thrombocytopenia (ITP) is an immunologically mediated bleeding disorder in which autoantibodies against platelet antigens cause premature platelet […]

COVID-19 and Hypercoagulability

H&O What are the manifestations of COVID-19 that relate to coagulation? MS The manifestations of coronavirus disease 2019 (COVID-19) that relate to coagulation appear to […]

Defining Treatment Duration in Atypical Hemolytic Uremic Syndrome in Adults: A Clinical and Pathological Approach

Abstract: Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy (TMA) that is driven by uncontrolled activation of the alternative complement pathway, classically in the […]

Highlights in Nonmalignant Hematology From the 2019 American Society of Hematology Meeting

December 7-10, 2019, Orlando, Florida Complement Inhibition Shows Promise in Autoimmune Hematologic Disorders Two recent studies support the use of sutimlimab, an investigational inhibitor of […]

Cold Agglutinin Disease: Where Do We Stand, and Where Are We Going?

Abstract: Primary cold agglutinin disease (CAD) is characterized by a very indolent bone marrow clonal B-cell lymphoproliferative disorder that initiates an autoimmune hemolytic anemia. The […]

The Use of Direct Oral Anticoagulants in Antiphospholipid Syndrome

H&O What is antiphospholipid syndrome, and what causes it? HC Antiphospholipid syndrome (APS) is an acquired autoimmune thrombophilia that is characterized by thrombosis and/or pregnancy […]

Update on Transfusion-Related Acute Lung Injury

H&O How did you become interested in transfusion-related acute lung injury? PT I became interested in transfusion-related acute lung injury (TRALI) in 2002 when a […]

Diagnosis and Treatment of Hemophilia

Abstract: Hemophilia A and B are inherited bleeding disorders characterized by deficiency or dysfunction of coagulation protein factors VIII and IX, respectively. Recurrent joint and […]

How I Treat Cold Agglutinin Hemolytic Anemia

Overview • Cold agglutinin disease is an immune-mediated hemolytic anemia characterized by complement on the red cell surface. • In half of patients, observation is […]

Antiplatelet Agents for Preventing Vaso-occlusive Events in People With Sickle Cell Disease: A Systematic Review

Abstract: Background: Sickle cell disease (SCD) is the most common hemoglobinopathy, occurring worldwide, and vaso-occlusive events (VOEs) are its paramount, hallmark clinical manifestation. Evidence exists […]

Diagnosis and Treatment of Cold Agglutinin Disease

H&O How common is cold agglutinin disease? CR Cold agglutinin disease is rare, with an estimated incidence of approximately 1 per million. H&O What causes […]

Diagnosing or Ruling Out Polycythemia Vera in Patients With Erythrocytosis

H&O How is erythrocytosis defined? JP Erythrocytosis is the presence of too many red blood cells. Several different parameters are used to diagnose erythrocytosis in […]

New Paradigms and Therapies for Iron Replacement in Iron Deficiency Anemia

H&O Who is a candidate for iron replacement? MA Anyone who is iron deficient is a candidate for iron replacement. Examples include women who are […]

Immune-Mediated Hemolytic Anemia and Thrombocytopenia in Clonal B-Cell Disorders: A Review

Abstract: Autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia purpura (ITP) have been associated with B-cell lymphoproliferative disorders. Here, we review the epidemiology, pathogenesis, diagnosis, and […]