Current Issue: June 2025
Feature Article
Non–Clear Cell Renal Cell Carcinoma: Unpacking a Messy Term
Abstract: Non–clear cell renal cell carcinoma (nccRCC) is a heterogeneous category comprising approximately 25% of epithelial renal tumors. Unlike their far more common clear cell counterpart, […]
Letter From the Editor
Letter From the Editor: What Would You Do?
As oncologists, how many times have we had to answer the question, “What would you do?” There is always the temptation to answer it with a […]
Lung Cancer in Focus
The Use of Biomarkers in Advanced, Locally Advanced, and Early-Stage Lung Cancer
H&O How has biomarker testing evolved differently for early-stage vs advanced lung cancer? NF We have good data regarding the use of biomarkers for neoadjuvant therapy […]
Melanoma in Focus
Update on LAG3 and Immunotherapy Combinations in Melanoma
H&O How does the mechanism of action of LAG3-targeted therapies differ from that of other immune checkpoint inhibitors? HT LAG3-targeted therapy unlocks an entirely new pathway […]
Advances in Drug Development
Intrathecal Immunotherapy in Patients Who Have Melanoma With Leptomeningeal Disease
H&O What is the rationale behind the use of immunotherapy for intrathecal treatment of leptomeningeal disease (LMD)? ICG When we talk about treatments before the new […]
CLL
The Development of BTK Degraders for Patients With Relapsed CLL
H&O What are Bruton tyrosine kinase (BTK) degraders, and how do they differ from BTK inhibitors? AD BTK degraders are from a new class of molecules, […]
Supplements:
Navigating the Paroxysmal Nocturnal Hemoglobinuria (PNH) Landscape
Abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disorder in which a somatic mutation in PIGA leads to reduced or absent expression of […]
The Promise of Molecular Residual Disease (MRD) Testing for Patients With Colorectal Cancer
Abstract: Molecular residual disease (MRD) assays using circulating tumor DNA (ctDNA) have the potential to detect colorectal cancer recurrence earlier than current standard-of-care surveillance techniques, such as […]