Archive: March 2021

Update on Antibody-Drug Conjugates in Breast Cancer

Hope S. Rugo, MD

H&O  How do antibody-drug conjugates (ADCs) work? HR  These anticancer drugs have a fascinating construct that combines an antibody, a toxin, and a linker. The idea […]

The Evolving Use of Gemtuzumab Ozogamicin in Acute Myeloid Leukemia

Roland B. Walter, MD, PhD, MS

H&O  What type of drug is gemtuzumab ozogamicin? RW  Gemtuzumab ozogamicin (Mylotarg, Pfizer) is an antibody-drug conjugate that consists of a humanized anti-CD33 antibody attached to […]

Circulating Tumor DNA in Early-Stage Breast Cancer: New Directions and Potential Clinical Applications

Sarah Croessmann, PhD, and Ben Ho Park, MD, PhD

Abstract: The use of circulating tumor DNA (ctDNA) in liquid biopsy as a biomarker is becoming the new paradigm for the screening and surveillance of breast […]

Antibody Treatment in Multiple Myeloma

Kathryn T. Maples, PharmD, Catherine Johnson, PA-C, and Sagar Lonial, MD

Abstract: Antibody therapy, which has become a critical option in the treatment of multiple myeloma (MM), includes monoclonal antibodies, antibody-drug conjugates, and bispecific antibodies. Anti-CD38 and […]

New Treatments for Patients With Progressive Metastatic Urothelial Carcinoma

Jonathan E. Rosenberg, MD

H&O Does urothelial carcinoma pose any challenges or opportunities for the development of new drugs? JR  Urothelial carcinoma tends to affect older patients, who often have […]

Highlights in COVID-19 From the 62nd American Society of Hematology Annual Meeting

Highlights in COVID-19 From the 62nd American Society of Hematology Annual Meeting December 5-8, 2020, Virtual The high incidence of venous thromboembolism (VTE) and its consequent […]

Hem/Onc News

Devon Schuyler

Tepotinib Receives Accelerated Approval for Metastatic Non–Small Cell Lung Cancer On February 3, the US Food and Drug Administration (FDA) granted accelerated approval to tepotinib (Tepmetko, […]

Letter From the Editor: It’s the Path that Matters

Richard R. Furman, MD

All physicians have certain patients who make an impression on them. I currently am taking care of an extraordinary 85-year-old woman who has already taught me […]

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