Feature Article

Hematologic Concerns in Transgender Patients

Abstract: Patients with gender dysphoria are increasingly seeking gender-affirming therapies, which can have adverse hematologic effects. For example, estrogen can increase the risk for arterial and […]

Feature Article

New Treatment Strategies for Waldenström Macroglobulinemia

Abstract: The development of high-throughput technologies has allowed us to characterize the molecular landscape of hematologic neoplasms and identify somatic mutations. As a result, we can […]

Advances in LLM

The Future Role of Bispecific Antibodies in Lymphoma

H&O What is the mechanism of action of bispecific antibodies? JA Bispecific antibodies aim to harness the power of the immune system. These treatments are monoclonal […]

CRC in Focus

The Emerging Role of KRAS G12C Inhibitors in the Treatment of Locally Advanced or Metastatic Colorectal Cancer

H&O How common are KRAS G12C mutations in locally advanced or metastatic colorectal cancer? KC RAS mutations overall are quite common in colorectal cancer (CRC) and […]

Letter From the Editor

I Think the FDA Got It Wrong …

We have experienced a string of great successes in clinical therapeutics for CLL over the past several years, both in the number of novel therapies approved […]

CLL

Clinical Use of Measurable Residual Disease in CLL

H&O What are some of the limitations of the International Workshop on CLL (iwCLL) response criteria for chronic lymphocytic leukemia (CLL) in the era of novel […]

Prostate Cancer In Focus

When to Use Somatic Tumor Testing in Prostate Cancer

H&O Which patients with prostate cancer are eligible for somatic tumor testing? TF To begin with, we should be clear about some definitions. Somatic tumor testing […]