Feature Article

Immune Checkpoint Inhibitor Therapy in Locally Advanced MSI GI Malignancies

Abstract: Locally advanced gastrointestinal (GI) malignancies have conventionally been treated in a multimodal fashion that combines (neo)adjuvant chemotherapy with or without radiation and definitive surgical resection. […]

Feature Article

Increasing Inclusion and Equity for Black Women in Breast Cancer Clinical Trials

Abstract: Black women diagnosed with breast cancer experience a disproportionately high mortality rate. The disparity in outcomes between Black and White women is multifactorial, with a […]

Advances in LLM

The Development of Menin Inhibitors in AML and ALL

H&O What are menin inhibitors, and how do they function in the context of acute myeloid leukemia/acute lymphoblastic leukemia? GI Menin inhibitors are a new form […]

Advances in Drug Development

PROTAC Drugs in Cancer Care

H&O What are PROTACs, and how do they target proteins in cancer treatment? PF Proteolysis-targeting chimeras (PROTACs) are a new class of drugs that, in my […]

Colorectal Cancer

Liver Transplant in Patients With Metastatic Colorectal Cancer

H&O How common are liver-limited metastases in colorectal cancer (CRC)? BA Approximately one-third of patients with metastatic CRC (mCRC) have metastases that are isolated to the […]

Case Study Series

Case Study Series: Improving Outcomes in Pediatric NTRK Gene Fusion-Positive Solid Tumors: Importance of Genomic Testing and Targeted Therapy With the TRK Inhibitor Larotrectinib

In the Clinic: Case Studies Let us begin our discussion with 2 pediatric cases that prompt the question, “How will you proceed?” Patient 1: A baby […]