Archive: May 2025
Feature Article
Genetics of Prostate Cancer
Abstract: Prostate cancer is a highly heritable cancer, with contributions from rare pathogenic variants in prostate cancer predisposition genes (eg, HOXB13, BRCA2) and from common genetic […]
Advances in Drug Development
The Development of ATR Inhibitors
H&O What is the ataxia telangiectasia and Rad3-related (ATR) protein, and what makes it a good target in cancer? TY The ATR protein is a serine […]
Gynecologic Cancer in Focus
Advances in Uterine Serous Carcinoma and Uterine Carcinosarcoma
H&O Uterine serous carcinoma and uterine carcinosarcoma have distinct molecular and histologic profiles. How do these differences affect prognosis? GF Uterine serous carcinoma and uterine carcinosarcoma […]
Lung Cancer in Focus
Radiation Therapy and MRI-Based Treatments in Non–Small Cell Lung Cancer
H&O How has the role of radiation therapy in non–small cell lung cancer (NSCLC) evolved in recent years? PL Historically, radiation therapy with concurrent chemotherapy in […]
Advances in LLM
Development of Chimeric Antigen Receptor Natural Killer–Cell Therapy
H&O What is chimeric antigen receptor natural killer (CAR NK)-cell therapy? KR Most people are familiar with the groundbreaking work done with CAR T-cell therapy, which […]
CRC in Focus
Treatment Deintensification in Locally Advanced Rectal Cancer: When Less Is More
H&O Why is it so important to determine which components of treatment can be omitted in patients with locally advanced rectal cancer? AC The treatment modalities […]