STEAP1 as a Potential Target for New Therapies in Prostate Cancer

H&O What is six-transmembrane epithelial antigen of prostate 1 (STEAP1)? WKK STEAP1 was first described more than 2 decades ago. It is a cell-surface antigen that […]

New Staging Systems in Nonmetastatic Prostate Cancer

H&O How is prognosis typically estimated in nonmetastatic prostate cancer? FF We typically estimate prognosis with a variety of tools, including the Gleason score; levels of […]

When to Use Germline Genetic Testing in Prostate Cancer

H&O What germline DNA repair gene mutations play a role in prostate cancer? VG Many DNA repair genes play a role in hereditary prostate cancer. These […]

Combination Therapy With Radium-223 and Enzalutamide in Castration-Resistant Prostate Cancer

H&O What question was your recent study in The Oncologist designed to answer? BLM We recently published the final results of our phase 2 study, which […]

The Role of AR-V7 Testing in the Management of Metastatic CRPC

H&O What is the rationale behind detection of the androgen receptor splice variant 7 (AR-V7) protein in men with prostate cancer? AA Prostate cancer is a […]

How Quality of Life Can Help Guide Selection of Androgen Receptor Inhibitors in Nonmetastatic Castration-Resistant Prostate Cancer

H&O What are the treatment goals for men with nonmetastatic, castration-resistant prostate cancer (CRPC)? MS Men with nonmetastatic, castration-resistant prostate cancer are at substantial risk for […]

PSMA-Targeted Radiotherapy in Metastatic Castration-Resistant Prostate Cancer

H&O Could you describe the design of the VISION study that was recently published? OS The phase 3 VISION trial, which was recently published in the […]

Emerging Role for Local Therapy in Oligometastatic Prostate Cancer

Abstract: Oligometastatic prostate cancer is a subtype of metastatic disease that generally is defined by the presence of 5 or fewer metastatic lesions. Metastatic prostate cancer […]

New Approaches to Targeting the Androgen Receptor Pathway in Prostate Cancer

Abstract: The androgen signaling axis has been the main therapeutic target in the management of advanced prostate cancer for several decades. Over the past years, significant […]

PSMA-Targeted Therapy in Prostate Cancer

H&O What is prostate-specific membrane antigen (PSMA), and what makes it a good target for the treatment of prostate cancer? ST PSMA is a cell surface […]

Contemporary Management of Advanced Prostate Cancer: An Evolving Landscape

Abstract: Recent population-based studies suggest that the incidence of advanced and metastatic prostate cancer may be increasing. Concurrently with this apparent stage migration toward advanced disease, […]

PARP Inhibitors in Prostate Cancer: Practical Guidance for Busy Clinicians

Abstract: The management of prostate cancer entered a new era of biomarker-driven therapy in May of 2020, when the US Food and Drug Administration (FDA) […]

The Role of Radiation Treatment in Metastatic Prostate Cancer

H&O What is the evidence to support irradiation of the primary tumor in metastatic prostate cancer? BK The main evidence comes from the STAMPEDE trial, […]

Highlights in Prostate Cancer From the 2020 American Society of Clinical Oncology Annual Meeting

May 29-31, 2020 • Virtual 68Ga-PSMA-11 PET Has Poor Sensitivity, Good Specificity for Pelvic Nodal Metastases 68Ga-PSMA-11 positron emission tomography (PET) has poor sensitivity and […]

Antibody-Drug Conjugates in Prostate Cancer

H&O What makes antibody-drug conjugates a good choice in treating cancer overall? DD Antibody-drug conjugates (ADCs) are designed to deliver potent cytotoxic agents directly to […]

Prostate Cancer in African American Men

H&O Can you discuss the disparities between black and white American men in terms of prostate cancer incidence and death rates? SP The good news […]

Focal Therapy for Prostate Cancer: Recent Advances and Future Directions

Abstract: Prostate cancer is the most frequently diagnosed cancer in men after skin cancer. Owing to the rising popularity of prostate-specific antigen screening, large numbers […]

Assessing the Risk of Cognitive Impairment Among Men With Prostate Cancer

H&O How prevalent is cognitive impairment in men with prostate cancer? CR Prostate cancer preferentially affects older men, and the older population in general is […]

Prostate Cancer in Military Veterans

H&O How much of your work is with military veterans? BM I have worked at the VA Puget Sound Health Care System for the past […]

Imaging of Prostate Cancer With Positron Emission Tomography

Abstract Prostate cancer is most commonly imaged through a combination of magnetic resonance imaging, x-ray computed tomography, and 99mTc-methylene diphosphonate bone scan. These conventional imaging […]