Archive: December 2016
Feature Article
The Management of Psychological Issues in Oncology
Daniel C. McFarland, DO, and Jimmie C. Holland, MD
Abstract: Psychological issues in the cancer setting are highly prevalent and well documented, and can lead to adverse outcomes. Several series of guidelines have been […]
Kidney Cancer
VEGF Inhibitors in Renal Cell Carcinoma
Pankit Vachhani, MD, and Saby George, MD
Abstract: The arrival of targeted therapies—vascular endothelial growth factor (VEGF) pathway inhibitors and mammalian target of rapamycin (mTOR) inhibitors—and programmed death 1 (PD-1) inhibitors has […]
Breast Cancer
Is Precision Medicine Ready for Use in Breast Cancer?
Lajos Pusztai, MD, DPhil
H&O How do you define precision medicine? LP The term precision medicine is often used as shorthand for personalizing or tailoring treatment recommendations to the […]
Drug Development
The Seamless Approach to Drug Development in Oncology
Richard Pazdur, MD
H&O What are some drawbacks to the 3-phase approach to drug development? RP A major drawback to the conventional 3-phase program is that a stop […]
Melanoma
Is There a Role for Single-Agent MEK Inhibition in Melanoma?
Douglas Johnson, MD, MSCI
H&O Which MEK inhibitors have been approved for use in melanoma? DJ The US Food and Drug Administration has approved 2 MEK inhibitors for use in […]
Leukemia
Considerations in the Frontline Treatment of Chronic Lymphocytic Leukemia
Susan M. O’Brien, MD
H&O When is frontline therapy initiated in chronic lymphocytic leukemia (CLL)? SO The standard approach to CLL is still watch-and-wait. If patients are asymptomatic and […]
HCC In Focus
Liver Transplant and Hepatocellular Carcinoma
Clinical Advances in Hematology & Oncology December 2016, Volume 14, Issue 12 Robert Wong, MD, MS Assistant Clinical Professor of Medicine Director of Research and Education […]
Kidney Cancer
Kidney Cancer News
Cancer Vaccine Fails to Improve Survival in Metastatic Renal Cell Carcinoma The addition of the IMA901 multipeptide cancer vaccine to sunitinib (Sutent, Pfizer) did not […]
Letter From the Editor
Letter from the Editor: The End
Clinical Advances in Hematology & Oncology December 2016, Volume 14, Issue 12 To everything, turn, turn, turn / There is a season, turn, turn, turn […]