The Management of Psychological Issues in Oncology

Daniel C. McFarland, DO, and Jimmie C. Holland, MD

  Abstract: Psychological issues in the cancer setting are highly prevalent and well documented, and can lead to adverse outcomes. Several series of guidelines have been […]

VEGF Inhibitors in Renal Cell Carcinoma

Pankit Vachhani, MD, and Saby George, MD

  Abstract:  The arrival of targeted therapies—vascular endothelial growth factor (VEGF) pathway inhibitors and mammalian target of rapamycin (mTOR) inhibitors—and programmed death 1 (PD-1) inhibitors has […]

Is Precision Medicine Ready for Use in Breast Cancer?

Lajos Pusztai, MD, DPhil

  H&O  How do you define precision medicine? LP  The term precision medicine is often used as shorthand for personalizing or tailoring treatment recommendations to the […]

The Seamless Approach to Drug Development in Oncology

Richard Pazdur, MD

  H&O  What are some drawbacks to the 3-phase approach to drug development? RP  A major drawback to the conventional 3-phase program is that a stop […]

Is There a Role for Single-Agent MEK Inhibition in Melanoma?

Douglas Johnson, MD, MSCI

H&O  Which MEK inhibitors have been approved for use in melanoma? DJ  The US Food and Drug Administration has approved 2 MEK inhibitors for use in […]

Considerations in the Frontline Treatment of Chronic Lymphocytic Leukemia

Susan M. O’Brien, MD

  H&O  When is frontline therapy initiated in chronic lymphocytic leukemia (CLL)? SO  The standard approach to CLL is still watch-and-wait. If patients are asymptomatic and […]

Liver Transplant and Hepatocellular Carcinoma

Clinical Advances in Hematology & Oncology December 2016, Volume 14, Issue 12 Robert Wong, MD, MS Assistant Clinical Professor of Medicine Director of Research and Education […]

Kidney Cancer News

  Cancer Vaccine Fails to Improve Survival in Metastatic Renal Cell Carcinoma The addition of the IMA901 multipeptide cancer vaccine to sunitinib (Sutent, Pfizer) did not […]

Letter from the Editor: The End

Clinical Advances in Hematology & Oncology December 2016, Volume 14, Issue 12 To everything, turn, turn, turn / There is a season, turn, turn, turn    […]

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