Archive: March 2017
The Use of Immunotherapy in the First-Line Treatment of Lung Cancer
Naiyer A. Rizvi, MD
H&O How does immunotherapy in lung cancer work? NR There has been tremendous recent progress in the understanding of how immunotherapy works in lung cancer. […]
Leukemia
The New NCCN Guidelines for the Management of Myelofibrosis
Ruben A. Mesa, MD
H&O What is myelofibrosis? RM Myelofibrosis is a myeloproliferative neoplasm, a type of chronic leukemia. Myelofibrosis can evolve from an antecedent polycythemia vera or essential thrombocythemia, […]
Lymphoma
Natural Killer/T-Cell Lymphomas in Pediatric and Adolescent Patients
Amanda M. Termuhlen, MD
Abstract: Natural killer/T-cell (NK/T-cell) lymphomas are rare in children and adolescents and consist predominantly of nasal-type extranodal NK/T-cell lymphomas. More than half of pediatric/adolescent patients […]
Leukemia
BCL-2 As a Therapeutic Target in Chronic Lymphocytic Leukemia
Catherine Daniel, MD, and Anthony R. Mato, MD, MSCE
Abstract: Venetoclax (formerly ABT-199) was recently approved in the United States for the treatment of patients who have relapsed or refractory chronic lymphocytic leukemia (CLL) […]
Prostate Cancer
Prognostic and Predictive Biomarkers in Metastatic Castration-Resistant Prostate Cancer
Andrew J. Armstrong, MD, ScM
H&O What are biomarkers in the context of metastatic castration-resistant prostate cancer (mCRPC)? AJA Biomarkers are any manifestation of a biological process, particularly in patients, […]
Hematology
Prevention and Management of Thrombosis in Myeloproliferative Neoplasms
Mallika Sekhar, MBBS, MD, FRCP, FRCPath
H&O What are the various myeloproliferative neoplasms (MPNs)? MK The conventional BCR-ABL–negative MPN categories are polycythemia vera (PV), essential thrombocythemia (ET), myelofibrosis, unclassified MPN (MPN-U), chronic […]
Drug Development
The Evolving Role of Cyclin-Dependent Kinase Inhibitors in Cancer Management
Geoffrey I. Shapiro, MD, PhD
H&O What is the role of cyclin-dependent kinases, and why are they a target in cancer treatment? GS The cyclin-dependent kinases (CDKs) are a large […]
Letter From the Editor
Letter From the Editor: When Will We Beat R-CHOP?
Brad S. Kahl, MD
I was joking around with one of my AML colleagues a while back, teasing him about giving 7 + 3 chemotherapy. That recipe has been around […]