Feature Article

Treatment of Unresectable and Resectable Stage IV Colorectal Cancer

Abstract: Colorectal cancer is the third most commonly diagnosed cancer in the United States. Approximately 20% of patients have metastatic disease at diagnosis, and a proportion […]

Counterpoints

Does Combination Menopausal Hormone Therapy Increase the Risk of Breast Cancer?

In 2002, researchers from the Women’s Health Initiative (WHI) reported that menopausal hormone therapy (MHT) increases the risk of breast cancer. This widely publicized finding led […]

Advances in Hematology

Recombinant ADAMTS13 Concentrate in Thrombotic Thrombocytopenic Purpura

H&O What is thrombotic thrombocytopenic purpura (TTP), and how common is it? SC TTP is a disorder in which small vessel thrombosis occurs throughout the body […]

Advances in LLM

Should Ponatinib Be the Standard-of-Care Tyrosine Kinase Inhibitor in Ph+ ALL?

H&O How common is Philadelphia chromosome–positive (Ph+) acute lymphocytic leukemia (ALL)? EJ The Ph+ form of ALL is characterized by the presence of the t(9;22) translocation […]

Prostate Cancer In Focus

Targeted Therapy in Prostate Cancer: Beyond PSMA

H&O What are the limitations of prostate-specific membrane antigen (PSMA)–targeted therapy in prostate cancer? MM PSMA is a very good target in prostate cancer, but not […]

Advances in Drug Development

Tackling the Cancer Drug Shortage

H&O How bad is the chemotherapy drug shortage right now? EF The shortage is difficult to quantify. We do not know exactly how many patients’ therapy […]