Thrombotic Complications of Influenza and COVID-19 Infections

H&O  How often do influenza and COVID-19 lead to thrombotic complications? PN  The true incidence of thrombotic complications with influenza and COVID-19 is unclear. A study […]

Treatment of Less-Common Complications of Sickle Cell Disease

H&O  What are the most common complications of sickle cell disease? UO  Sickle cell disease is associated with several complications, both acute and chronic. The most […]

Principles of Gene Therapy for the Hematologist

H&O  What is the definition of gene therapy? JS  The most basic definition of gene therapy is the use of genes to prevent or treat disease. […]

Management of Antithrombin Deficiency

H&O  What is antithrombin deficiency? IP  Antithrombin deficiency refers to a decrease in the natural clotting inhibitor, antithrombin. Antithrombin is important because it inhibits clotting factors, […]

Beyond Factor Replacement Therapy: New and Experimental Agents for Hemophilia

H&O  What are the limitations of factor VIII administration to prevent and treat bleeding in hemophilia? AV  Factor VIII administration entails frequent intravenous infusions, which require […]

Prevention and Treatment of Venous Thromboembolism in Primary and Metastatic Brain Cancer

H&O  How many people develop brain cancer each year in the United States, and which types of cancer are most likely to lead to brain metastases?  […]

Pyruvate Kinase Deficiency: Clinical Expression and New Therapies

H&O  What is pyruvate kinase (PK) deficiency? HA  PK deficiency is a hereditary hemolytic anemia that is the most common cause of congenital, chronic non-spherocytic hemolytic […]

How Early Intervention Impacts Long-Term Survival in Myelofibrosis

H&O  What are the signs and symptoms indicating that a patient with myelofibrosis requires treatment?  SV  According to standard practice, there are typically 3 indications for […]

New Strategies for the Treatment of Immune Thrombocytopenia

H&O  Which guidelines should physicians refer to when taking care of patients with immune thrombocytopenia (ITP)?  CK  The American Society of Hematology (ASH) published updated guidelines […]

Update on Pure Red Cell Aplasia: Etiology, Diagnosis, and Treatment

H&O What is the definition of pure red cell aplasia (PRCA)? RM PRCA is a normochromic, normocytic anemia that is associated with an extremely low reticulocyte […]

The Use of ADAMTS13 Assays in Thrombotic Microangiopathies

H&O  What are thrombotic microangiopathies (TMAs), and how common are they? SC  TMAs are clinical syndromes in which blood clots occur in the smallest blood vessels […]

Diagnosis and Treatment of Upper Extremity Deep Vein Thrombosis and Thoracic Outlet Syndrome

Clinical Advances in Hematology & Oncology March 2016, Volume 14, Issue 3 Ying-Wei Lum, MD Assistant Professor of Surgery Division of Vascular Surgery and Endovascular Therapy […]

Can Global Assays Make Anticoagulation Safer and More Effective?

Clinical Advances in Hematology & Oncology January 2016, Volume 14, Issue 1   H. Coenraad Hemker, MD, PhD Emeritus Professor Cardiovascular Research Institute Maastricht Maastricht, the […]

The Effect of ICD-10-CM Coding on Nonmalignant Hematology

Clinical Advances in Hematology & Oncology November 2015, Volume 13, Issue 11 Andrew D. Boyd, MD Assistant Professor Biomedical and Health Information Sciences College of Applied […]

Contraception in Women With Hereditary Thrombophilic Defects

Michiel Coppens, MD, PhD Internist, Vascular Medicine Academic Medical Center Amsterdam, The Netherlands H&O How common is thrombophilia in women of childbearing age? MC The term thrombophilia […]

The Potential Threat to Blood Transfusion Safety of Emerging Infectious Disease Agents

Clinical Advances in Hematology & Oncology July 2015, Volume 13, Issue 7   Susan L. Stramer, PhD Vice President, Scientific Affairs American Red Cross Gaithersburg, Maryland […]

The New Paradigm for Transfusion of Platelets

Clinical Advances in Hematology & Oncology May 2015, Volume 13, Issue 5   Richard M. Kaufman, MD Medical Director, Adult Transfusion Service, Brigham and Women’s Hospital, Assistant Professor […]

The Shifting Paradigm for Transfusion of Red Blood Cells

Clinical Advances in Hematology & Oncology March 2015, Volume 13, Issue 3   Jeffrey L. Carson, MD, Richard C. Reynolds Professor of Medicine, Chief, Division of General Internal Medicine, Rutgers Robert […]

Understanding Bleeding in Ebola Virus Disease

Clinical Advances in Hematology & Oncology January 2015, Volume 13, Issue 1 Anita McElroy, MD, PhD, Assistant Professor, Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia H&O […]

Blood Component Support in Patients With Solid Tumors and Hematologic Malignancies: Lessons From the Treatment of Jehovah’s Witnesses

Clinical Advances in Hematology & Oncology December 2014, Volume 12, Issue 12 Kaaron Benson, MD, Medical Director, Blood Bank/HLA Laboratory, Moffitt Cancer Center, Tampa, Florida H&O  When are blood […]