Feature Article

Multikinase Inhibitors in Refractory Metastatic Colorectal Cancer: An Optimal Sequence?

Abstract: Despite major advances in management strategies, metastatic colorectal cancer remains an important clinical challenge because most patients experience progression after standard first- and second-line treatments. […]

Feature Article

The Clinical Applications of Next-Generation Sequencing and ctDNA/cfDNA in Lymphoma

Abstract: Next-generation sequencing (NGS) technology plays a pivotal role in understanding the molecular landscape in oncology by providing a comprehensive analysis of genomic mutations. The detection […]

Melanoma in Focus

The Evolution of Treatment for Uveal Melanoma

H&O What distinguishes uveal melanoma from cutaneous melanoma biologically? SK Although these 2 tumors are both melanomas—they have the same cell of origin, the melanocyte—they are […]

Advances in LLM

Use of Menin Inhibitors for Acute Leukemia

H&O What is the mechanism of action of menin inhibitors? GI Menin inhibitors are a new class of drugs for patients with acute leukemia that work […]

Advances in Drug Development

Adoptive Cell Therapy for Ovarian Cancer

H&O What are the shortcomings of existing therapies for ovarian cancer? KO Standard therapy in patients with newly diagnosed ovarian cancer consists of neoadjuvant chemotherapy followed […]

Letter From the Editor

Letter From the Editor: Ambassadors for Hope

Oncology is a hard field to be in at any time of the year, but especially now. It’s winter, the holidays are over, and the days […]

CLL in Focus

Fixed-Duration vs Continuous Treatment for Chronic Lymphocytic Leukemia in the CLL17 Trial

H&O What was the impetus for the CLL17 trial? OA Over the past 5 to 10 years, we have seen the evolution of 2 treatment paradigms […]