The Diagnosis and Treatment of Red Cell Membrane Disorders: Algorithm for the General Hematologist

H&O What is the first step in evaluating a patient with hemolysis? TK The first step is to take a history and conduct a physical examination. […]

Diagnosis and Treatment of Secondary Hemophagocytic Lymphohistiocytosis in Adults

H&O What is hemophagocytic lymphohistiocytosis (HLH), and what forms of it occur? JR HLH is a hyperinflammatory response—an overactivation of the immune system that is driven […]

Thrombosis in Immune Thrombocytopenia

H&O What is immune thrombocytopenia (ITP), and what causes it? HL ITP is an autoimmune disorder that causes a significant decrease in the blood platelet count, […]

Recombinant ADAMTS13 Concentrate in Thrombotic Thrombocytopenic Purpura

H&O What is thrombotic thrombocytopenic purpura (TTP), and how common is it? SC TTP is a disorder in which small vessel thrombosis occurs throughout the body […]

Thrombotic Complications of Influenza and COVID-19 Infections

H&O How often do influenza and COVID-19 lead to thrombotic complications? PN The true incidence of thrombotic complications with influenza and COVID-19 is unclear. A study […]

Treatment of Less-Common Complications of Sickle Cell Disease

H&O What are the most common complications of sickle cell disease? UO Sickle cell disease is associated with several complications, both acute and chronic. The most […]

Principles of Gene Therapy for the Hematologist

H&O What is the definition of gene therapy? JS The most basic definition of gene therapy is the use of genes to prevent or treat disease. […]

Management of Antithrombin Deficiency

H&O What is antithrombin deficiency? IP Antithrombin deficiency refers to a decrease in the natural clotting inhibitor, antithrombin. Antithrombin is important because it inhibits clotting factors, […]

Beyond Factor Replacement Therapy: New and Experimental Agents for Hemophilia

H&O What are the limitations of factor VIII administration to prevent and treat bleeding in hemophilia? AV Factor VIII administration entails frequent intravenous infusions, which require […]

Prevention and Treatment of Venous Thromboembolism in Primary and Metastatic Brain Cancer

H&O How many people develop brain cancer each year in the United States, and which types of cancer are most likely to lead to brain metastases? […]

Pyruvate Kinase Deficiency: Clinical Expression and New Therapies

H&O What is pyruvate kinase (PK) deficiency? HA PK deficiency is a hereditary hemolytic anemia that is the most common cause of congenital, chronic non-spherocytic hemolytic […]

How Early Intervention Impacts Long-Term Survival in Myelofibrosis

H&O What are the signs and symptoms indicating that a patient with myelofibrosis requires treatment? SV According to standard practice, there are typically 3 indications for […]

New Strategies for the Treatment of Immune Thrombocytopenia

H&O Which guidelines should physicians refer to when taking care of patients with immune thrombocytopenia (ITP)? CK The American Society of Hematology (ASH) published updated guidelines […]

Update on Pure Red Cell Aplasia: Etiology, Diagnosis, and Treatment

H&O What is the definition of pure red cell aplasia (PRCA)? RM PRCA is a normochromic, normocytic anemia that is associated with an extremely low reticulocyte […]

The Use of ADAMTS13 Assays in Thrombotic Microangiopathies

H&O What are thrombotic microangiopathies (TMAs), and how common are they? SC TMAs are clinical syndromes in which blood clots occur in the smallest blood vessels […]

Diagnosis and Treatment of Upper Extremity Deep Vein Thrombosis and Thoracic Outlet Syndrome

Clinical Advances in Hematology & Oncology March 2016, Volume 14, Issue 3 Ying-Wei Lum, MD Assistant Professor of Surgery Division of Vascular Surgery and Endovascular Therapy […]

Can Global Assays Make Anticoagulation Safer and More Effective?

Clinical Advances in Hematology & Oncology January 2016, Volume 14, Issue 1 H. Coenraad Hemker, MD, PhD Emeritus Professor Cardiovascular Research Institute Maastricht Maastricht, the […]

The Effect of ICD-10-CM Coding on Nonmalignant Hematology

Clinical Advances in Hematology & Oncology November 2015, Volume 13, Issue 11 Andrew D. Boyd, MD Assistant Professor Biomedical and Health Information Sciences College of Applied […]

Contraception in Women With Hereditary Thrombophilic Defects

Michiel Coppens, MD, PhD Internist, Vascular Medicine Academic Medical Center Amsterdam, The Netherlands H&O How common is thrombophilia in women of childbearing age? MC The term thrombophilia […]

The Potential Threat to Blood Transfusion Safety of Emerging Infectious Disease Agents

Clinical Advances in Hematology & Oncology July 2015, Volume 13, Issue 7 Susan L. Stramer, PhD Vice President, Scientific Affairs American Red Cross Gaithersburg, Maryland […]