From Recent Issues

Non–Clear Cell Renal Cell Carcinoma: Unpacking a Messy Term

Abstract: Non–clear cell renal cell carcinoma (nccRCC) is a heterogeneous category comprising approximately 25% of epithelial renal tumors. Unlike their far more common clear cell counterpart, […]

Genetics of Prostate Cancer

Abstract: Prostate cancer is a highly heritable cancer, with contributions from rare pathogenic variants in prostate cancer predisposition genes (eg, HOXB13, BRCA2) and from common genetic […]

Update on PARP Inhibitors for the Treatment of Ovarian Cancer

Abstract: Poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors (PARPis) were first granted US Food and Drug Administration (FDA) approval for ovarian cancer. Trials have focused on high-grade serous […]

Supplements

Navigating the Paroxysmal Nocturnal Hemoglobinuria (PNH) Landscape

Abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disorder in which a somatic mutation in PIGA leads to reduced or absent expression of […]

The Promise of Molecular Residual Disease (MRD) Testing for Patients With Colorectal Cancer

Abstract: Molecular residual disease (MRD) assays using circulating tumor DNA (ctDNA) have the potential to detect colorectal cancer recurrence earlier than current standard-of-care surveillance techniques, such as […]

Modern Approaches in Neuroendocrine Tumors (NETs)

In the Clinic: Case Studies The following 2 patient cases highlight the clinical complexity of neuroendocrine tumors (NETs), and the widely different approaches in pancreatic NETs […]