From Recent Issues

The Clinical Applications of Next-Generation Sequencing and ctDNA/cfDNA in Lymphoma

Abstract: Next-generation sequencing (NGS) technology plays a pivotal role in understanding the molecular landscape in oncology by providing a comprehensive analysis of genomic mutations. The detection […]

Multikinase Inhibitors in Refractory Metastatic Colorectal Cancer: An Optimal Sequence?

Abstract: Despite major advances in management strategies, metastatic colorectal cancer remains an important clinical challenge because most patients experience progression after standard first- and second-line treatments. […]

What Cancer Patients May or May Not Be Surprised to Know About Survivorship

Abstract: The number of US cancer survivors has increased from fewer than 4 million in the 1970s to 18.1 million in 2022, with the increase reflecting […]

Supplements

Ravulizumab–Danicopan Combination Therapy in PNH Management

In the Clinic AB presented to our clinic in 2017, at the age of 70, for a second opinion regarding management of paroxysmal nocturnal hemoglobinuria (PNH) […]

Translating FRESCO Clinical Trial Evidence Into Practice: Fruquintinib as Post–Standard Third-Line Therapy Followed by Trifluridine/Tipiracil in a Patient With mCRC Without Targetable Mutations

In the Clinic JR is a 54-year-old male who was diagnosed with left-side transverse colon adenocarcinoma metastatic to the peritoneum and liver (Table 1). A next-generation […]

Navigating the Paroxysmal Nocturnal Hemoglobinuria (PNH) Landscape

Abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disorder in which a somatic mutation in PIGA leads to reduced or absent expression of […]