Archive: March/April 2025

Is There a New Standard-of-Care Therapy for Advanced Hodgkin Lymphoma?

H&O  What has been the traditional treatment for patients with advanced Hodgkin lymphoma? AH  The traditional treatment for patients with stage III or IV Hodgkin lymphoma […]

Management of Toxicities From Antibody-Drug Conjugates

H&O  Which antibody-drug conjugates (ADCs) are approved for use in breast cancer? HR  The first ADC to be approved for use in breast cancer was trastuzumab […]

Targeting RAS in Gastrointestinal Malignancies

Abstract: Kirsten rat sarcoma virus (KRAS) is one of the prevalent oncogenic drivers in gastrointestinal (GI) cancers, including pancreatic ductal adenocarcinoma and colorectal cancer. The KRAS […]

Update on PARP Inhibitors for the Treatment of Ovarian Cancer

Abstract: Poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors (PARPis) were first granted US Food and Drug Administration (FDA) approval for ovarian cancer. Trials have focused on high-grade serous […]

PARP Inhibition in HRR Gene–Mutated Metastatic Castration-Resistant Prostate Cancer

H&O  What role do mutations in homologous recombination repair (HRR) genes play in metastatic castration-resistant prostate cancer (mCRPC)? TD  We have recently come to realize that […]

Thrombosis in Immune Thrombocytopenia

H&O  What is immune thrombocytopenia (ITP), and what causes it?  HL  ITP is an autoimmune disorder that causes a significant decrease in the blood platelet count, […]

Ethics in Medicine: Avoiding Conflicts of Interest in Prescribing

H&O  What are some potential sources of conflict of interest that physicians may encounter in prescribing? GVN  The main conflict of interest is the one that […]

The Use of Fixed-Dose Regimens in Chronic Lymphocytic Leukemia

H&O  What fixed-dose regimens are in use in chronic lymphocytic leukemia (CLL)? AK  Fixed-duration regimens have been used for a long time in patients with CLL. […]

Letter From the Editor: A Common Cause

Practicing in Durham, North Carolina, I have the privilege of caring for a wide range of patients—Black and White, old and young, rich and poor. People […]

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